Приказ основних података о документу

dc.creatorSoković, Marina
dc.creatorRashed, Khaled N
dc.creatorGlamočlija, Jasmina
dc.creatorĆirić, Ana D.
dc.creatorCalhelha, Ricardo C
dc.creatorFerreira, Isabel CFR
dc.date.accessioned2017-11-23T11:27:49Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued2013sr
dc.identifier.issn2314-6133sr
dc.identifier.otherRad_konverzija_3042sr
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/1047
dc.description.abstractThe hydromethanolic extract of Sapindus saponaria L. aerial parts was investigated for antimicrobial activity (against several Gram-positive and Gram-negative bacteria and fungi) and capacity to inhibit the growth of different human tumor cell lines as also nontumor liver cells. The evaluated extract was further characterized in terms of phytochemicals using UV, H-1-NMR, C-13-NMR, and MS spectroscopic tools. The extract has shown a significant antimicrobial activity on all tested bacterial and fungal species. The best activity was achieved against Bacillus cereus and Staphylococcus aureus among bacteria and against all three Penicillium species tested. It also revealed cytotoxicity against human colon (HCT-15), cervical (HeLa), breast (MCF-7), and lung (NCI-H460) carcinoma cell lines, with HeLa being the most susceptible tumor cell line. The extract was not toxic for nontumor liver cells. Chromatographic separation of the extract resulted in the isolation and identification of stigmasterol, oleanolic acid, luteolin, luteolin 8-C-beta-glucoside (orientin), luteolin 6-C-beta-glucoside (isoorientin), luteolin 7-O-beta-glucuronide, and rutin. The results of the present findings may be useful for the discovery of novel antitumor and antimicrobial agents from plant origin.en
dc.description.sponsorshipFCT; POPH-QREN; FSE [SFRH/BD/78307/2011]; Serbian Ministry of Education and Science [173032]; [PEst-OE/AGR/UI0690/2011]sr
dc.language.isoEnglishsr
dc.sourceBiomed Research Internationalsr
dc.titleAntimicrobial Activity, Growth Inhibition of Human Tumour Cell Lines, and Phytochemical Characterization of the Hydromethanolic Extract Obtained from Sapindus saponaria L. Aerial Partsen
dc.typearticle
dcterms.abstractЦалхелха, Рицардо Ц; Расхед, Кхалед Н; Гламочлија, Јасмина; Соковић, Марина; Ћирић, Aна Д.; Ферреира, Исабел ЦФР;
dc.citation.issuenullsr
dc.citation.volumenullsr
dc.citation.spage361sr
dc.citation.epagenasr


Документи

ДатотекеВеличинаФорматПреглед

Нема фајлова за овај рад.

Овај рад се појављује у следећим колекцијама

Приказ основних података о документу