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dc.creatorBlagojević, Duško P.
dc.creatorOreščanin Dušić, Zorana
dc.creatorMilovanović, Slobodan R
dc.creatorRadojičić, Ratko M.
dc.creatorNikolić-Kokić, Aleksandra
dc.creatorAppiah, Isabella
dc.creatorSlavić, Marija
dc.creatorCutura, Neđo D
dc.creatorTrbojević, Stevan
dc.creatorSpasić, Mihajlo B.
dc.date.accessioned2017-11-23T11:27:36Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued2009sr
dc.identifier.issn0231-5882sr
dc.identifier.otherRad_konverzija_3470sr
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/1475
dc.description.abstractProtamine sulphate (PS) effect on spontaneous and calcium-induced rhythmic contractions of isolated virgin rat uteri was studied. PS caused dose-dependent relaxation of both types of contractions (two-way ANOVA, significant dose effects). Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME; 10(-5) mol/l), methylene blue (MB; 0.9 x 10(-6) mol/l) or propranolol (1.7 x 10(-5) mol/l) enhanced PS-mediated uterine muscle relaxation of spontaneous contractions. Dose-dependent relaxation of spontaneous active isolated rat uterus with PS was lower in uteri pretreated with single dose of tetraethylammonium (TEA; 6 x 10(-3) mol/l), glibenclamide (2 x 10(-6) mol/l) and 4-aminopyridine (4-AP; 10(-3) mol/l). Calcium-induced activity of the isolated rat uterus pretreated with the same concentration of L-NAME, MB, or propranolol modified the kinetic of PS-induced relaxation without changes in EC(50) values. Pre-treatment with glibenclamide, TEA and 4-AP significantly reduce PS relaxing effect of calcium-induced activity and according to EC(50) values the order of magnitude was glibenclamide > TEA > 4-AP. PS is mixture of polyamines and may activate different signal-transduction pathways. Our results cleary demonstrate that in uterine smooth muscle PS act dominantly through potassium chanels and marginaly through beta-adrenergic receptos or nitric oxide-dependent pathways.en
dc.description.sponsorshipMinistry of Science of the Republic of Serbia [143034B]sr
dc.language.isoEnglishsr
dc.sourceGeneral Physiology and Biophysicssr
dc.titleEffects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediateden
dc.typearticle
dcterms.abstractБлагојевић, Душко П.; Миловановић, Слободан Р; Орешчанин Душић, Зорана; Николић-Кокић, Aлександра; Спасић, Михајло Б.; Трбојевић, Стеван; Цутура, Неђо Д; Славић, Марија; Aппиах, Исабелла; Радојичић, Ратко М.;
dc.citation.issuenullsr
dc.citation.volume28sr
dc.citation.epage148sr


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