Приказ основних података о документу

dc.creatorRaicević, Nevena
dc.creatorMladenović Đorđević, Aleksandra
dc.creatorPerović, Milka
dc.creatorMiljković, Đorđe M.
dc.creatorTrajković, Vladimir S
dc.date.accessioned2017-11-23T11:15:09Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued2005sr
dc.identifier.issn0077-8923sr
dc.identifier.otherRad_konverzija_3635sr
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/1640
dc.description.abstractTreatment with 6-hydroxydopamine significantly reduced the viability of cultured rat primary astrocytes, rat astrocytoma cell line C6, and human astrocytoma cell line U251. 6-Hydroxydopamine-treated astrocytes exhibited altered nuclear morphology, DNA fragmentation, and reduced intracellular esterase activity, which indicated apoptotic cell death. Astrocytes were protected by neutralization of 6-hydroxydopamine autooxidation products H2O2, O-2, and -OH, but not by cell-derived or chemically generated anti-apoptotic free radical nitric oxide. Finally, 6-hydroxydopamine activated extracellular signal-regulated kinase in astrocytes and selective inhibitor of extracellular signal-regulated kinase activation partially prevented astrocyte death. Taken together, these data indicate that 6-hydroxydopamine-triggered oxidative stress induces extracellular signal-regulated kinase-dependent apoptotic death of astrocytes.en
dc.description.sponsorshipnullsr
dc.language.isoEnglishsr
dc.sourceBiophysics from Molecules to Brain: in Memory of Radoslav K. Andjussr
dc.titleThe mechanisms of 6-hydroxydopamineInduced astrocyte deathen
dc.typeconferenceObject
dcterms.abstractТрајковић, Владимир С; Миљковић, Ђорђе М.; Раицевић, Невена; Младеновић Ђорђевић, Aлександра; Перовић, Милка;
dc.citation.issuenullsr
dc.citation.volume1048sr
dc.citation.epage405sr


Документи

ДатотекеВеличинаФорматПреглед

Нема фајлова за овај рад.

Овај рад се појављује у следећим колекцијама

Приказ основних података о документу