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dc.creatorKataranovski, Milena V.
dc.creatorVlaski, Marija
dc.creatorKataranovski, Dragan S.
dc.creatorTosić, N
dc.creatorMandić-Radić, Slavka
dc.creatorTodorović, Vera N
dc.date.accessioned2017-11-23T11:15:27Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued2003sr
dc.identifier.issn0300-483Xsr
dc.identifier.otherRad_konverzija_3759sr
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/1764
dc.description.abstractThe immunotoxicity of epicutaneously administered anticoagulant rodenticide warfarin (WF) was examined in this work by using experimental contact hypersensitivity (CHS) reaction to hapten dinitrochlorobenzene (DNCB). WF (0.05 and 0.5 mg/kg) administration 24 h before the induction of CHS does not change expression of CHS evaluated by ear swelling assay. Regional draining lymph node response during sensitization phase was characterized by decreased cellularity but increased spontaneous and IL-2 stimulated proliferation of draining lymph node cells (DLC). No changes in IL-2 production and in numbers of CD25(+) cells were noted and even decreased proliferative index (ratio of IL-2 stimulated to unstimulated DLC proliferation) was detected. Increase in granulocyte activity (MTT reduction and adhesion to plastic) was noted following application of WF solely with further increase following subsequent application of DNCB, when granulocyte activation (NBT reduction) was noted also. Access of WF into general circulation might be responsible for observed changes, what was supported by ex vivo changes in DLC and granulocyte functions assessed before initiation of sensitization and by in vitro effect of exogenous WF as well. Differential effects of WF on lymphocytes and granulocytes noted in this study highlight the need for simultaneous testing of both cell type activity what might constitute a more integrated approach in immunotoxicity studies. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.en
dc.description.sponsorshipnullsr
dc.language.isoEnglishsr
dc.sourceToxicologysr
dc.titleImmunotoxicity of epicutaneously applied anticoagulant rodenticide warfarin: evaluation by contact hypersensitivity to DNCB in ratsen
dc.typearticle
dcterms.abstractКатарановски, Милена В.; Катарановски, Драган С.; Тосић, Н; Тодоровић, Вера Н; Мандић-Радић, Славка; Власки, Марија;
dc.citation.issue1sr
dc.citation.volume188sr
dc.citation.epage100sr


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