Farmakološki in vitro skrining centralnih monoaminoergičnih efekata ekstrakata Valeriana officinalis
Pharmacological in vitro screening of the central monoaminergic effects of Valeriana officinalis extracts
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Pharmaceutical preparations of valerian root and rhizome (Valeriana officinal is L., Valerianaceae) have widespread use for sedation and treatment of hysteric states, anxiety, stress and insomnia (Morazzoni and Bombardelli 1995; Houghton, 1999; Weiss and Fintelmann, 2000; Cropley et al., 2002). Pharmacological investigations of valerian were mostly concentrated on the components of the essential oil - valerenic acids, non-glycosidated iridoids named valepotriates and its degradative products - baldrinals, but also on several lignans.