Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells
Аутори:Srdjenovic, Branislava U.
Slavic, Marija N.
Stankov, Karmen M.
Kladar, Nebojsa V.
Jovic, Danica S.
Seke, Mariana N.
Bogdanovic, Visnja V.
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Fullerenol (C-60(OH)(24)) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which have cytoprotective and anti-oxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10\% fetal bovine serum (FBS) and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1) survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin C-treated cell line. Our investigation implies that FNP, as a strong antioxidant, influences the cellular redox state and enzyme activities and thus may reduce cell proliferation, which confirms that FNP could be exploited for its use as a cytoprotective agent.