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dc.creatorBlaževski, Jana
dc.creatorPetković, Filip
dc.creatorMomčilović, Miljana B.
dc.creatorJevtić, Bojan
dc.creatorStojkovic, Marija Mostarica
dc.creatorMiljković, Đorđe
dc.date.accessioned2016-05-23T10:59:43Z
dc.date.issued2015
dc.identifier.issn0171-2985
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/1937
dc.description.abstractIt has been increasingly appreciated that tumor necrosis factor (TNF) performs various protective and anti-inflammatory functions in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Recently, CXCL12 has been identified as a key inhibitor of leukocyte entry into the central nervous system (CNS) and as a regulator of inflammation resulting from the invasion. Here, a positive correlation between expression of TNF and CXCL12 in the CNS samples of EAE rats is presented. Also, it is shown that TNF potentiates CXCL12 expression in astrocytes. These results contribute to a view that TNF produced within the CNS plays a protective role in neuroinflammation. (C) 2015 Elsevier GmbH. All rights reserved.
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia {[}173035, 175038, 173013]
dc.languageEnglish
dc.sourceImmunobiology
dc.subjectExperimental autoimmune encephalomyelitis
dc.subjectTumor necrosis factor
dc.subjectAstrocyte
dc.subjectNeuroinflammation
dc.titleTumor necrosis factor stimulates expression of CXCL12 in astrocytes
dc.typearticle
dcterms.abstractЈевтић, Бојан; Петковић, Филип; Миљковић, Ђорђе М.; Момчиловић, Миљана Б.; Блажевски, Јана; Стојковиц, Марија Мостарица;
dc.citation.issue7
dc.citation.volume220
dc.identifier.doi10.1016/j.imbio.2015.01.007
dc.identifier.scopus2-s2.0-84929507535
dc.identifier.wos000356317000001
dc.citation.spage845
dc.citation.epage850
dc.type.versionpublishedVersionen
dc.citation.rankM22


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