Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro
Ćirić, Ana D.
Markovic, Jasmina D.
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This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95\%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.
Кључне речи:Anti-biofilm activity; Anti-quorum sensing effects; Flavonoids; Pseudomonas aeruginosa PAO1
Извор:Current Pharmaceutical Biotechnology, 2015, 16, 8, 733-737