4-Thiazolidinone derivatives as potent antimicrobial agents: microwave-assisted synthesis, biological evaluation and docking studies
2015
Аутори:
Pitta, EleniTsolaki, Evangelia
Geronikaki, Athina
Petrovic, Jovana
Glamočlija, Jasmina

Soković, Marina

Crespan, Emmanuele
Maga, Giovanni
Bhunia, Shome S.
Saxena, Anil K.
Тип документа:
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт:
As a part of our ongoing research in the development of new
antimicrobials, herein, we report the synthesis of ten compounds which
combine three bioactive moieties: thiazole, adamantane and
4-thiazolidinone. Evaluation of their antibacterial activity revealed
that the newly synthesized compounds exhibited remarkable growth
inhibition of a wide spectrum of Gram-positive bacteria, Gram-negative
bacteria and fungi. The majority of the compounds displayed greater
antibacterial activity than the reference drugs (ampicillin and
streptomycin), while the antifungal activity was significantly higher
than that of the reference drugs bifonazole and ketoconazole.
Additionally, the title compounds were screened for HIV-1 reverse
transcriptase inhibitory activity, showing no significant activity.
Moreover, docking studies were performed in order to explore possible
binding modes at the MurB protein of S. aureus.
Извор:
Medchemcomm, 2015, 6, 2, 319-326
DOI: 10.1039/c4md00399c
ISSN: 2040-2511