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dc.creatorVojnović-Milutinović, Danijela
dc.creatorNikolic, Marina
dc.creatorDinic, Jovana
dc.creatorĐorđević, Ana D.
dc.creatorVelickovic, Natasa
dc.creatorElaković, Ivana
dc.creatorMatić, Gordana
dc.creatorBrkljačić, Jelena
dc.date.accessioned2016-05-23T11:00:43Z
dc.date.available2016-05-23T11:00:43Z
dc.date.issued2014
dc.identifier.issn1821-4339
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/2273
dc.description.abstractAlterations in leptin and glucocorticoid signaling pathways in the hypothalamus of male and female rats subjected to a fructose-enriched diet were studied. The level of expression of the key components of the leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway (glucocorticoid receptor /GR/, 11 beta-hydroxysteroid dehydrogenase type 1 /11 beta HSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not differ between fructose-fed rats and control animals of both genders. However, in females, a fructose-enriched diet provoked increases in the adiposity index, plasma leptin and triglyceride concentrations, and displayed a tendency to decrease the leptin receptor (ObRb) protein and mRNA levels. In male rats, the fructose diet caused elevations in plasma non-esterified fatty acids and triglycerides, as well as in both plasma and hypothalamic leptin concentrations. Our results suggest that a fructose-enriched diet can induce hyperleptinemia in both female and male rats, but with a more pronounced effect on hypothalamic leptin sensitivity in females, probably contributing to the observed development of visceral adiposity.
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia {[}III41009]
dc.languageEnglish
dc.sourceArchives of Biological Sciences
dc.subjectFructose diet
dc.subjecthypothalamus
dc.subjectleptin
dc.subjectleptin receptor
dc.subjectglucocorticoids
dc.subjectglucocorticoid receptor
dc.titleLeptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats
dc.typearticle
dcterms.abstractЂорђевић, Aна Д.; Велицковиц, Натаса; Матић, Гордана М.; Елаковић, Ивана; Несторов, Јелена; Војновић-Милутиновић, Данијела; Диниц, Јована; Николиц, Марина;
dc.citation.issue2
dc.citation.volume66
dc.identifier.doi10.2298/ABS1402829M
dc.identifier.scopus2-s2.0-84903981177
dc.identifier.wos000342265800042
dc.citation.spage829
dc.citation.epage839
dc.type.versionpublishedVersionen


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