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Soy extract-dependent changes in morphofunctional parameters of the pituitary corticotropes in adult rats

2014
Аутори:
Trifunovic, Svetlana
Manojlović-Stojanoski, Milica
Ajdžanović, Vladimir
Nestorović, Nataša M.
Ristic, Natasa
Šošić-Jurjević, Branka T.
Milosevic, Verica
Тип документа:
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Апстракт:
Numerous studies have established a link between estrogen levels and activity of the hypothalamic pituitary adrenal (HPA) system. Considering the ``weak estrogenic{''} effect of soy isoflavones, this study was designed to evaluate the influence of soy extract treatment on some morphofunctional parameters of rat pituitary corticotropes in vivo. Adult male orchidectomized Wistar rats received estradiol-dipropionate or soy extract in oil/ethanol solvent subcutaneously for 3 weeks. Both controls, sham-operated (So) and orchidectomized (Orx) rats, were injected with solvent, in the same regime. Changes in pituitary volume, total volume, total number and volume of individual corticotropes were evaluated stereologically, while ACTH levels were determined biochemically. In comparison with So rats, estradiol treatment provoked increases (p < 0.05) of ACTH level (166\%), pituitary weight (167\%) and volume (102\%), total volume (20\%) and total number of corticotropes (18\%). In comparison to Orx, following estradiol treatment elevation (p < 0.05) of ADE level (69\%), pituitary weight (131\%) and volume (82\%), total (30\%) and individual volume (29\%) of corticotropes was observed. Soy extract treatment led to enhancement (p < 0.05) of: ACTH level (28\%), total (25\%) and individual volume (20\%) of corticotropes. It can be concluded that soy extract acts in a similar way to estradiol, but the increased activity of corticotropes was weaker. (C) 2013 Elsevier GmbH. All rights reserved.
Кључне речи:
Soy extract; Corticotropes; Rats; Stereology
Извор:
Acta Histochemica, 2014, 116, 5, 717-722

DOI: 10.1016/j.acthis.2013.12.010

ISSN: 1618-0372

WoS: ISI:000340011900009

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URI
http://ibiss-r.rcub.bg.ac.rs/123456789/2281
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