Biomarkeri oksidacionog stresa i koncentracija metala u odabranim tkivima belouške (Natrix natrix) i ribarice (Natrix tessellata) sa područja Obedske bare i Pančevačkog rita
Oxidative stress biomarkers and metal concentrations in selected tissues of grass snake (Natrix natrix) and dice snake (Natrix tessellata) from Obedska bara and Pančevački rit
Doctoral thesis (Published version)
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Ecotoxicological studies are important due to the fact they can have a practicalapplication in environmental protection. Semiaquatic snakes are continuously exposedto various complex environmental factors both in aquatic and terrestrial environment.They are long-living organisms, on the top of the food chain, with smaller movementradius compared to most birds and mammals, which makes them ideal model organismsfor monitoring effects of exposure to different types of xenobiotics in naturalconditions.Metals are the most widespread group of pollutants. Due to their toxicity,biomagnification along the food chain, as well as biological effects they cause, theyrepresent indispensable link in ecotoxicological research.The aim of this doctoral thesis was to examine seasonal dynamics of oxidativestress biomarkers, the impact of metals present in the environment, as well as theirbioaccumulation in some tissues of Natrix natrix (Grass snake) and Natrix tessellata(Dice snake) from Special Nature Reserve sites, Obedska bara and Pančevački rit,industrial zone, for periods before and after hibernation. In blood, liver, kidney, muscleand adipose tissue, enzyme components of system protection against oxidative damagewere analyzed: activities of total, manganese and copper zinc superoxide dismutase (TotSOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px) andglutathione reductase (GR), non-enzymatic components of system protection againstoxidative damage: concentration of glutathione (GSH) and free sulfhydryl groups (SH),biochemical indicator of oxidative damage (TBARS), phase I biotransformationenzyme: cytochrome P4501A (CYP1A), phase II biotransformation enzyme: glutathione-S-transferase (GST), biomarkers of exposure to metals, metallothionein and activity ofcholinesterase (ChE), neurotoxicity biomarker.In water, liver and muscle tissues, alkaline (Li, K), alkaline earth metal (Ba, Ca,Mg), transient (Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Zn), weak (Al, Pb ) metals andmetalloid As were analyzed...
Keywords:Oxidative stress biomarkers; Semiaquatic snakes; Metals; Obedska bara; Pančevački rit
Source:University of Belgrade, Faculty of Biology, 2015, 1-212
- Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress (RS-173041)
APA:Gavrić, J. (2015). Biomarkeri oksidacionog stresa i koncentracija metala u odabranim tkivima belouške (Natrix natrix) i ribarice (Natrix tessellata) sa područja Obedske bare i Pančevačkog rita. University of Belgrade, Faculty of Biology.
Vancouver:Gavrić J. Biomarkeri oksidacionog stresa i koncentracija metala u odabranim tkivima belouške (Natrix natrix) i ribarice (Natrix tessellata) sa područja Obedske bare i Pančevačkog rita [dissertation]. Belgrade: University of Belgrade, Faculty of Biology; 2015. 212 p.
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