РАДаР - Репозиторијум Архивираних Дигиталних Радова
Институт за биолошка истраживања "Синиша Станковић"
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ИБИСС РАДаР
  • IBISS
  • Article
  • Преглед рада
  •   ИБИСС РАДаР
  • IBISS
  • Article
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

Comparative studies on osmosis based encapsulation of sodium diclofenac in porcine and outdated human erythrocyte ghosts

2016
Аутори:
Bukara, Katarina
Drvenica, Ivana
Ilić, Vesna
Stančić, Ana
Mišić, Danijela
Vasić, Borislav
Gajić, Radoš
Vučetić, Dušan
Kiekens, Filip
Bugarski, Branko
Тип документа:
Чланак у часопису
Метаподаци
Приказ свих података о документу
Апстракт:
The objective of our study was to develop controlled drug delivery system based on erythrocyte ghosts for amphiphilic compound sodium diclofenac considering the differences between erythrocytes derived from two readily available materials – porcine slaughterhouse and outdated transfusion human blood. Starting erythrocytes, empty erythrocyte ghosts and diclofenac loaded ghosts were compared in terms of the encapsulation efficiency, drug releasing profiles, size distribution, surface charge, conductivity, surface roughness and morphology. The encapsulation of sodium diclofenac was performed by an osmosis based process – gradual hemolysis. During this process sodium diclofenac exerted mild and delayed antihemolytic effect and increased potassium efflux in porcine but not in outdated human erythrocytes. FTIR spectra revealed lack of any membrane lipid disorder and chemical reaction with sodium diclofenac in encapsulated ghosts. Outdated human erythrocyte ghosts with detected nanoscale damages and reduced ability to shrink had encapsulation efficiency of only 8%. On the other hand, porcine erythrocyte ghosts had encapsulation efficiency of 37% and relatively slow drug release rate. More preserved structure and functional properties of porcine erythrocytes related to their superior encapsulation and release performances, define them as more appropriate for the usage in sodium diclofenac encapsulation process.
Кључне речи:
Controlled drug delivery; Encapsulation; Erythrocyte membranes; Gradual hypotonic hemolysis; Pharmaceutical biotechnology; Slaughterhouse blood
Извор:
Journal of Biotechnology, 2016, 240, 14-22

DOI: 10.1016/j.jbiotec.2016.10.017

[ Google Scholar ]
URI
http://linkinghub.elsevier.com/retrieve/pii/S0168165616315735
https://www.scopus.com/record/display.uri?eid=2-s2.0-84992192143&origin=SingleRecordEmailAlert&txGid=694651161B2E63C5600F6DE538B0ACEC.wsnAw8kcdt7IPYLO0V48gA:3
http://ibiss-r.rcub.bg.ac.rs/123456789/2525
Колекције
  • Article
Институција
IBISS

DSpace software copyright © 2002-2015  DuraSpace
О ИБИСС РАДаР репозиторијуму | Пошаљите запажања

OpenAIRERCUB
 

 

Комплетан репозиторијумКолекцијеАуториПо датуму издавањаТемеОва институцијаАуториПо датуму издавањаТеме

DSpace software copyright © 2002-2015  DuraSpace
О ИБИСС РАДаР репозиторијуму | Пошаљите запажања

OpenAIRERCUB