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dc.contributor.authorMiler, Marko
dc.contributor.authorŽivanović, Jasmina
dc.contributor.authorAjdžanović, Vladimir
dc.contributor.authorOreščanin-Dušić, Zorana
dc.contributor.authorMilenković, Dragan
dc.contributor.authorKonić-Ristić, Aleksandra
dc.contributor.authorBlagojević, Duško
dc.contributor.authorMilošević, Verica
dc.contributor.authorŠošić-Jurjević, Branka
dc.date.accessioned2017-03-29T12:35:36Z
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S053155651630290X
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/2689
dc.description.abstractThis study aimed to investigate effects of citrus flavanones naringenin (NAR) and hesperetin (HES) on liver antioxidant status and membrane phospholipid composition in 24-month-old rats. NAR and HES (15 mg/kg) were administrated orally to male Wistar rats, once per day, for 4 weeks. Control group received either vehicle (sunflower oil) or remained intact. The results showed decreased (p < 0.05) activity of antioxidant enzymes (AOE), specifically catalase (CAT), superoxide dismutase (SOD) 1 and glutathione reductase (GR) in the liver of intact control old-aged rats in comparison to young intact controls. Flavanone administration to old-aged males increased (p < 0.05) examined AOE activities in comparison to vehicle-administered animals. Namely, NAR was more potent in comparison to HES regarding the increase (p < 0.05) in activities of examined antioxidant enzymes (SOD 1 and 2, glutathione peroxidase-GPx and GR) and the liver glutathione (GSH), while HES elevated (p < 0.05) only activity of CAT and GR. Both flavanones significantly decreased (p < 0.05) TBARS and improved (p < 0.05) membrane phospholipid composition in favor of n-3 PUFA and n-6/n-3 PUFA ratio. Both flavanones did not affect liver histology and reduced (p < 0.05) alanine aminotransferase and aspartate aminotransferase levels in serum. The results of this study indicate beneficial potential of citrus flavanones in the old-aged rat liver.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173009/RS//
dc.sourceExperimental Gerontology
dc.subjectAntioxidant system
dc.subjectCitrus flavanones
dc.subjectLiver
dc.subjectOld age rats
dc.subjectPhospholipid composition
dc.subject.otherm21
dc.titleCitrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats
dc.typeArticle
dc.rights.holder© 2016 Elsevier Inc.
dc.identifier.doi10.1016/j.exger.2016.08.014
dc.identifier.wos000385490900006
dc.citation.volume84
dc.citation.spage49
dc.citation.epage60
dc.identifier.pmid27587005
dc.citation.apaMiler, M., Živanović, J., Ajdžanović, V., Oreščanin-Dušić, Z., Milenković, D., Konić-Ristić, A., Blagojević, D., et al. (2016). Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Experimental Gerontology, 84, 49–60.
dc.citation.vancouverMiler M, Živanović J, Ajdžanović V, Oreščanin-Dušić Z, Milenković D, Konić-Ristić A, Blagojević D, Milošević V, Šošić-Jurjević B. Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Exp Gerontol. 2016;84:49–60.
dc.description.otherExperimental Gerontology (2016), 84: 49-60
dc.identifier.scopus2-s2.0-84984829170


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