Приказ основних података о документу

dc.creatorMiler, Marko
dc.creatorŽivanović, Jasmina
dc.creatorAjdžanović, Vladimir
dc.creatorOreščanin Dušić, Zorana
dc.creatorMilenković, Dragan
dc.creatorKonić-Ristić, Aleksandra
dc.creatorBlagojević, Duško
dc.creatorMilošević, Verica
dc.creatorŠošić-Jurjević, Branka
dc.date.accessioned2017-03-29T12:35:36Z
dc.date.available2017-11-23T11:33:58Z
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S053155651630290X
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/2689
dc.description.abstractThis study aimed to investigate effects of citrus flavanones naringenin (NAR) and hesperetin (HES) on liver antioxidant status and membrane phospholipid composition in 24-month-old rats. NAR and HES (15 mg/kg) were administrated orally to male Wistar rats, once per day, for 4 weeks. Control group received either vehicle (sunflower oil) or remained intact. The results showed decreased (p < 0.05) activity of antioxidant enzymes (AOE), specifically catalase (CAT), superoxide dismutase (SOD) 1 and glutathione reductase (GR) in the liver of intact control old-aged rats in comparison to young intact controls. Flavanone administration to old-aged males increased (p < 0.05) examined AOE activities in comparison to vehicle-administered animals. Namely, NAR was more potent in comparison to HES regarding the increase (p < 0.05) in activities of examined antioxidant enzymes (SOD 1 and 2, glutathione peroxidase-GPx and GR) and the liver glutathione (GSH), while HES elevated (p < 0.05) only activity of CAT and GR. Both flavanones significantly decreased (p < 0.05) TBARS and improved (p < 0.05) membrane phospholipid composition in favor of n-3 PUFA and n-6/n-3 PUFA ratio. Both flavanones did not affect liver histology and reduced (p < 0.05) alanine aminotransferase and aspartate aminotransferase levels in serum. The results of this study indicate beneficial potential of citrus flavanones in the old-aged rat liver.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173009/RS//
dc.rightsclosedAccess
dc.sourceExperimental Gerontology
dc.subjectAntioxidant system
dc.subjectCitrus flavanones
dc.subjectLiver
dc.subjectOld age rats
dc.subjectPhospholipid composition
dc.subject.otherm21
dc.titleCitrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиленковић, Драган; Благојевић, Душко; Милер, Марко; Aјджановић, Владимир; Шошић-Јурјевић, Бранка; Милошевић, Верица; Живановић, Јасмина; Орешчанин Душић, Зорана; Конић-Ристић, Aлександра;
dc.rights.holder© 2016 Elsevier Inc.
dc.citation.volume84
dc.description.otherExperimental Gerontology (2016), 84: 49-60
dc.identifier.doi10.1016/j.exger.2016.08.014
dc.identifier.pmid27587005
dc.identifier.scopus2-s2.0-84984829170
dc.identifier.wos000385490900006
dc.citation.apaMiler, M., Živanović, J., Ajdžanović, V., Oreščanin-Dušić, Z., Milenković, D., Konić-Ristić, A., Blagojević, D., et al. (2016). Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Experimental Gerontology, 84, 49–60.
dc.citation.vancouverMiler M, Živanović J, Ajdžanović V, Oreščanin-Dušić Z, Milenković D, Konić-Ristić A, Blagojević D, Milošević V, Šošić-Jurjević B. Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Exp Gerontol. 2016;84:49–60.
dc.citation.spage49
dc.citation.epage60


Документи

Thumbnail

Овај рад се појављује у следећим колекцијама

Приказ основних података о документу