Interactions of Pannexin1 channels with purinergic and NMDA receptor channels
Stojilković, Stanko S.
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Pannexins are a three-member family of vertebrate plasma membrane spanning molecules that have homology to the invertebrate gap junction forming proteins, the innexins. However, pannexins do not form gap junctions but operate as plasma membrane channels. The best-characterized member of these proteins, Pannexin1 (Panx1) was suggested to be functionally associated with purinergic P2X and N-methyl-D-aspartate (NMDA) receptor channels. Activation of these receptor channels by their endogenous ligands leads to cross-activation of Panx1 channels. This in turn potentiates P2X and NMDA receptor channel signaling. Two potentiation concepts have been suggested: enhancement of the current responses and/or sustained receptor channel activation by ATP released through Panx1 pore and adenosine generated by ectonucleotidase-dependent dephosphorylation of ATP. Here we summarize the current knowledge and hypotheses about interactions of Panx1 channels with P2X and NMDA receptor channels. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.
Keywords:ATP; Megapore; NMDA receptors; P2X receptors; Pannexin1; Purinergic receptors
- Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-41014)
- National Natural Science Foundation of China No. 31572645 (S.L.) (-)
- Intramural Research Program of the National Institute of Child Health and Human Development ProjectZIA HD 000195-22 (-)
In: Biochimica et Biophysica Acta (BBA) - Biomembranes (2017)