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dc.creatorSaksida, Tamara
dc.creatorMiljković, Đorđe
dc.creatorDekanski, Dragana P.
dc.creatorStojanović, Ivana
dc.creatorStošić-Grujičić, Stanislava
dc.date.accessioned2015-08-28T10:26:51Z
dc.date.available2015-08-28T10:26:51Z
dc.date.issued2011
dc.date.issued2011sr
dc.identifier.issn0354-4664sr
dc.identifier.otherRad_konverzija_339sr
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/277
dc.description.abstractWe have recently demonstrated the beneficial effects of dry olive leaf extract (DOLE) in two preclinical models of type 1 diabetes. Here we analyze the potential mechanisms underlying diabetes amelioration at the level of lymph node drainage. Treatment of C57BL/6 mice with DOLE during induction of diabetes with multiple low doses of streptozotocin (MLD-SZ) modulated cytokine expression and production in pancreatic lymph node cells, thereby changing the balance between potentially pathogenic and down-regulating cytokines. These results support the immunoregulatory potential of DOLE which takes place at the level of lymph node drainage and preserves the target tissue from autoimmune attack.en
dc.description.sponsorshipProjekat ministarstva br. 143029B i 173013sr
dc.language.isoengsr
dc.rightsopenAccesssr
dc.rightsopenAccess
dc.sourceArchives of Biological Sciencessr
dc.subjectAutoimmune diabetesENG
dc.subjectstreptozotocinENG
dc.subjectolive leaf extractENG
dc.subjectcytokineENG
dc.subjectinflammationENG
dc.subjectC57BL/6 miceENG
dc.titleDry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodesen
dc.typearticlesr
dc.rights.licenseBY-NC-ND
dcterms.abstractСаксида, Тамара; Декански, Драгана П.; Стошић-Грујичић, Станислава Д.; Миљковић, Д.; Стојановић, Ивана;
dc.rights.holder© 2015 Serbian Biological Society
dc.citation.issue2sr
dc.citation.volume63sr
dc.identifier.doi10.2298/ABS1102289S
dc.identifier.scopus2-s2.0-79961201670
dc.identifier.wos000291130000001
dc.citation.spage289sr
dc.citation.epage297sr
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/2265/Rad_konverzija_339.pdf
dc.citation.rankM23


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