Rani elektrofiziološki znaci poremećaja spavanja i motorne kontrole u starenju pacova sa neurodegeneracijom holinergičkih neurona
Early electrophysiological markers of the sleep and motor control disorders during aging in rats with neurodegeneration of the cholinergic neurons
Doctoral thesis (Published version)
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The aim of the present doctoral dissertation was to evaluate the impact of aging during sleep in the rat models of Alzheimer’s and Parkinson’s disease cholinergic neuropathology, and to determine the possible different and earlier onset of age-related sleep disorder during healthy aging and aging with the neurodegenerative diseases. We used the bilateral nucleus basalis (NB) and nucleus pedunculopontinus tegmentalis (PPT) lesioned rats as the in vivo models of functionally distinct cholinergic neuropathology, and we followed the impact of aging on sleep architecture, the electroencephalographic (EEG) microstructure and motor control across sleep/wake states. We evidenced the topographically distinct impact of healthy aging on sleep architecture and motor control within the sensorimotor (SMCx) vs. motor cortex (MCx). Whereas healthy aging consistently altered only the SMCx sleep architecture, it increased the delta and beta cortical drives from both cortices during Wake, but only through the MCx drive during rapid eye movement sleep (REM). Our results have shown for the first time that the earliest signs of aging during distinct cholinergic neuropathology were expressed through a different and topographically specific EEG microstructure during REM. EEG delta amplitude attenuation within the SMCx was the earliest sign of aging in the NB lesion, whereas EEG sigma amplitude augmentation within the MCx was the earliest sign of aging in the PPT lesion during REM. In addition, aging was differently expressed through the SMCx drive alterations, but it was commonly expressed through the MCx drive alterations during all sleep/wake states. This doctoral dissertation provided for the first time an evidence of distinct REM sleep disorders and sleep state related cortical drives as the signs of aging onset during functionally distinct cholinergic neuropathologies.
Keywords:Aging; Sleep; Motor control; Neurodegenerative diseases; Corticomuscular coherence (CMC); Nucleus basalis (NB); Nucleus pedunculopontinus tegmentalis (PPT); Cholinergic neuronal loss; Electroencephalography (EEG); Electromyography (EEG)
- Neurobiology of sleep in aging and disease - electroencephalographic markers and modeling in the estimation of disorder (RS-173022)