Strain-specific helper T cell profile in the gut-associated lymphoid tissue
2017
Аутори:
Stanisavljević, Suzana
Đedović, Neda

Vujičić, Milica

Saksida, Tamara

Jevtić, Bojan

Momčilović, Miljana

Miljković, Đorđe

Stojanović, Ivana

Milovanović, Boško
Тип документа:
Чланак у часопису

© 2017 European Federation of Immunological Societies
Метаподаци
Приказ свих података о документуАпстракт:
C57BL/6, BALB/c and NOD mice are among the most frequently used strains in autoimmunity research. NOD mice spontaneously develop type 1 diabetes (T1D) and they are prone to induction of experimental autoimmune encephalomyelitis (EAE). Both diseases can be routinely induced in C57BL/6 mice, but not in BALB/c mice. Also, C57BL/6 mice are generally considered T helper (Th)1-biased and BALB/c Th2-biased mice. Having in mind increasingly appreciated role of gut associated lymphoid tissue (GALT) cells in autoimmunity, especially in relation to gut Th17 and regulatory T (Treg) cells, our aim was to determine if there are differences in proportion of CD4 + T cell populations in mesenteric lymph nodes and Peyer's p atches of these mouse strains. Lower proportion of Treg was observed in NOD PP, Th2 cells dominated in BALB/c mice in mesenteric lymph nodes (MLN) and Peyer's patches (PP), while Th1 cells prevailed in C57BL/6 MLN. Intradermal immunization of mice with complete Freund's adjuvant resulted in significant difference in Th cell distribution in GALT of NOD mice. Differences were less pronounced in C57BL/6 mice, while GALT of BALB/c mice was almost unresponsive to the immunization. The observed strain- and tissue-dependent changes in Treg proportion after the immunization was probably a consequence of different CCR2 or CCR6-related migration patterns and/or in situ Treg proliferation. In conclusion, NOD, a highly autoimmunity-prone mouse strain, exhibits more profound GALT-related immune response upon immunization compared to the strains that are less prone to autoimmunity.
Кључне речи:
Type 1 diabetes; Multiple sclerosis; Autoimmunity; Gut-associated lymphoid tissue; ImmunizationПројекти:
- Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (RS-173013)
- Ћелијски и молекулски механизми опоравка пацова од експерименталног аутоимунског енцефаломијелитиса (RS-173035)
У: Immunology Letters (2017), 190: 282-288
URI
http://linkinghub.elsevier.com/retrieve/pii/S0165247817301979http://ibiss-r.rcub.bg.ac.rs/123456789/2854