Transdifferentiation of pancreatic alpha to beta cells using Epi-CRISPR directed DNA methylation
Arambašić Jovanović, Jelena
Jurkowski, Tomasz P.
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Since diabetes is characterized by impaired ability of pancreatic beta-cells to respond and/or produce insulin, new approaches for renewal and replacement of deficient beta-cells are indispensable. Generation of new insulin-producing cells from other cell types is a major aim of regenerative medicine. It has been shown that loss of the master regulatory transcription factor Arx is sufficient to induce the conversion of alpha cells to functional insulin-producing cells. Previous experiments revealed dedifferentiation of pancreatic beta to alpha cells in response to ablation of DNA methyltransferase 1 (Dnmt1) in beta cells.
Poster session presented at: CoMBoS. 1st Congress of Molecular Biologists of Serbia; 2017 Sep 20-22; Belgrade, Serbia. (P51-MBE)
internal-pdf://CoMBoS poster 2017 Marija Sinadinovic.pdf
- Signaling molecules in diabetes: search for potential targets in intrinsic pathways for prediction and intervention in diabetes (RS-173020)
1st Congress of Molecular Biologists of Serbia (2017)[ Google Scholar ]