Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters
Authors:Petrova, Krasimira T.
Barros, M. Teresa
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Article (Accepted Version)
© 2017 Springer Science+Business Media, LLC, part of Springer Nature
MetadataShow full item record
A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 6-O-methacryloyl sucrose 2 and 1′,2,3,3′,4,4′,6′-hepta-O-acetyl-6-O-methacryloyl sucrose 9 were the most active bactericides against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 0.24 and 1.40 μM. The compound 9 showed also the highest antifungal activity with MICs from 0.28 to 1.10 μM. The synthesized compounds possessed low cytotoxicity against human breast, lung, cervical, and hepatocellular carcinoma cell lines without showing toxicity for non-tumor liver cells. Thus, this library of short carbon chain unsaturated sucrose esters represent promising leads for the development of new generation of sucrose-based antimicrobial agents.
This is a pre-print of an article published in Medicinal Chemistry Research. The final authenticated version is available online at: https://doi.org/10.1007/s00044-017-2121-5
Keywords:Unsaturated esters; Sucrose; Antibacterial activity; Antifungal activity; Cytotoxic activity
Source:Medicinal Chemistry Research, 2017
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-173032)
- Fundação para a Ciência e a Tecnologia through grant nos. PEst-C/EQB/LA0006/2013 and PEst-OE/AGR/UI0690/2014