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dc.creatorSavić, Danka
dc.creatorKnežević, Goran
dc.creatorMatić, Gordana
dc.creatorDamjanović, Svetozar
dc.date.accessioned2018-04-12T08:50:55Z
dc.date.available2018-04-12T08:50:55Z
dc.date.issued2018
dc.identifier.urihttp://www.psyneuen-journal.com/article/S0306-4530(18)30088-X/fulltext
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3034
dc.description.abstractBACKGROUND Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. METHOD This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. RESULTS The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder - personality trait Disintegration. CONCLUSIONS According to our project results, DHEAS is the second putative biomarker for trauma-related disorders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/179018/RS//
dc.rightsclosedAccess
dc.sourcePsychoneuroendocrinology
dc.subjectDHEAS
dc.subjectDepression
dc.subjectPersonality traits
dc.subjectPost-traumatic stress disorder
dc.subjectStructure equation model
dc.subject.otherm21a
dc.titlePTSD and depressive symptoms are linked to DHEAS via personality.
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractКнежевић, Горан; Савић, Данка; Матић, Гордана; Дамјановић, Светозар;
dc.rights.holder© 2018 Elsevier Ltd.
dc.citation.volume92
dc.identifier.doi10.1016/j.psyneuen.2018.03.017
dc.identifier.pmid29621722
dc.identifier.scopus2-s2.0-85044739815
dc.citation.apaSavic, D., Knezevic, G., Matic, G., & Damjanovic, S. (2018). PTSD and depressive symptoms are linked to DHEAS via personality. Psychoneuroendocrinology, 92, 29–33.
dc.citation.vancouverSavic D, Knezevic G, Matic G, Damjanovic S. PTSD and depressive symptoms are linked to DHEAS via personality. Psychoneuroendocrinology. 2018;92:29–33.
dc.citation.spage29
dc.citation.epage33


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