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dc.creatorKaluđerović, Goran
dc.creatorBulatović, Mirna
dc.creatorKrajnović, Tamara
dc.creatorPaschke, Reinhard
dc.creatorB. Zmejkovski, Bojana
dc.creatorMaksimović-Ivanić, Danijela
dc.creatorMijatović, Sanja
dc.date.accessioned2018-04-26T10:30:00Z
dc.date.available2018-04-26T10:30:00Z
dc.date.issued2017
dc.identifier.urihttp://www.mdpi.com/2304-6740/5/3/56
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3042
dc.description.abstractSynthesis of platinum(II) conjugate with acetylated betulinic acid tris(hydroxymethyl)aminomethane ester (BATRIS) is presented (BATRISPt). HR-ESI-MS and multinuclear NMR spectroscopy, as well as elemental analysis were used for characterization of BATRISPt. Cytotoxicity (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), crystal violet (CV), and sulforhodamine B (SRB) assays) of BA, BATRIS, BATRISPt, and cisplatin were assessed on seven different tumor cell lines: melanoma B16, colon HCT116 and DLD-1, adenocarcinoma HeLa, breast MCF-7, and anaplastic thyroid tumor 8505C and SW1736; as well as normal MRC-5 fibroblasts. Furthermore, the effect of the mentioned compounds on the apoptosis (Annexin V/PI assay) and autophagy induction (acridine orange (AO) assay) as well as caspase 3, 8, and 9 activation were investigated on the selected B16 melanoma cell line. BATRISPt showed lower activity than BA, BATRIS, or cisplatin. All tested compounds triggered apoptosis in B16 cells. Induction of autophagy was observed in B16 cells exposed only to BATRIS. On the other hand, new conjugate activates caspases 8 and 9 in B16 cells with higher impact than BATRIS or cisplatin alone.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationGerman Academic Exchange Service (DAAD)
dc.rightsopenAccess
dc.sourceInorganics
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectBetulinic acid
dc.subjectCisplatin
dc.subjectDrug conjugate
dc.title(18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractКрајновић, Тамара; Пасцхке, Реинхард; Максимовић-Иванић, Данијела; Мијатовић, Сања; Калуђеровић, Горан; Булатовић, Мирна; Б. Змејковски, Бојана;
dc.rights.holder© 2017 by the authors.
dc.citation.issue3
dc.citation.volume5
dc.identifier.doi10.3390/inorganics5030056
dc.identifier.scopus2-s2.0-85045409497
dc.identifier.wos000412058700017
dc.citation.apaKaluđerović, G., Bulatović, M., Krajnović, T., Paschke, R., B. Zmejkovski, B., Maksimović-Ivanić, D., & Mijatović, S. (2017). (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity. Inorganics, 5(3), 56.
dc.citation.vancouverKaluđerović G, Bulatović M, Krajnović T, Paschke R, B. Zmejkovski B, Maksimović-Ivanić D, Mijatović S. (18-Crown-6)potassium(I) Trichlorido[28-acetyl-3-(tris-(hydroxylmethyl)amino-ethane)betulinic ester-κN]platinum(II): Synthesis and In Vitro Antitumor Activity. Inorganics. 2017;5(3):56.
dc.citation.spage56
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/handle/123456789/3042/Inorganics_2017_5_3_56.pdf


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