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dc.creatorMijatović, Sanja
dc.creatorBramanti, Alessia
dc.creatorNicoletti, Ferdinando
dc.creatorFagone, Paolo
dc.creatorKaluđerović, Goran N.
dc.creatorMaksimović-Ivanić, Danijela
dc.date2019-04-12
dc.date.accessioned2018-05-03T09:30:29Z
dc.date.available2018-05-03T09:30:29Z
dc.date.issued2018
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0734975018300739
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/29656090
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3045
dc.description.abstractDifferentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that potentially limits tumor progression and augments chemosensitivity. While this therapeutic strategy is already being used for treatment of hematological cancers, its feasibility for solid malignancies is still debated. We will presently discuss the natural compounds that show these properties, with focus on anthraquinones from Aloe vera, Senna, Rheum sp. and hop derived prenylflavonoids.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.relationIRCCS Centro Neurolesi “Bonino Pulejo”, Messina-Italy
dc.rightsembargoedAccess
dc.rightsembargoedAccess
dc.sourceBiotechnology Advances
dc.subjectAloe emodin
dc.subjectBlood tumors
dc.subjectBrain tumors
dc.subjectCancer
dc.subjectChemotherapy
dc.subjectDifferentiation based therapies
dc.subjectIsoxanthohumol
dc.subjectNaturally occurring compounds
dc.subjectNeurooncology
dc.subjectSolid tumors
dc.subjectTransdifferentiation
dc.subject.otherm21a
dc.titleNaturally occurring compounds in differentiation based therapy of cancer.
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractМијатовић, Сања; Калуђеровић, Горан Н.; Максимовић-Иванић, Данијела; Браманти, Aлессиа; Ницолетти, Фердинандо; Фагоне, Паоло;
dc.rights.holder© 2018 Elsevier Inc.
dc.identifier.doi10.1016/j.biotechadv.2018.04.001
dc.identifier.pmid29656090
dc.identifier.scopus2-s2.0-85045557392
dc.citation.apaMijatović, S., Bramanti, A., Nicoletti, F., Fagone, P., Kaluđerović, G. N., & Maksimović-Ivanić, D. (2018). Naturally occurring compounds in differentiation based therapy of cancer. Biotechnology Advances, DOI:10.1016/j.biotechadv.2018.04.001.
dc.citation.vancouverMijatović S, Bramanti A, Nicoletti F, Fagone P, Kaluđerović GN, Maksimović-Ivanić D. Naturally occurring compounds in differentiation based therapy of cancer. Biotechnol Adv. 2018;DOI:10.1016/j.biotechadv.2018.04.001.
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