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dc.creatorUskoković, Aleksandra
dc.creatorDinić, Svetlana
dc.creatorGrdović, Nevena
dc.creatorArambašić Jovanović, Jelena
dc.creatorVidaković, Melita
dc.creatorPoznanović, Goran
dc.creatorMihailović, Mirjana
dc.date.accessioned2018-06-04T13:02:04Z
dc.date.available2018-06-04T13:02:04Z
dc.date.issued2018
dc.identifier.urihttp://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641800023U
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3072
dc.description.abstractThis review summarizes the effects of α-lipoic acid (LA) on liver damage and complications in diabetes and drug toxicity. LA is a naturally occurring dithiol compound that plays an essential role in mitochondrial metabolism in its protein-bound form. In contrast, free LA in supplements has diverse biological actions, and its antioxidant effect is its most studied and important activity. Due to its strong antioxidant potential, LA could have a promising role in the treatment of pathologies resulting from an imbalance in redox homeostasis. This includes diabetes, which produces deleterious effects on many organs, including the liver. In diabetes specifically, LA prevents β-cell destruction, enhances glucose uptake, and its antioxidant effects may be particularly useful in slowing down the development of diabetic complications. Diabetes-related liver damage is a serious complication in which oxidative stress is the main contributor to tissue injury. Oxidative stress is regarded as one of the main pathological mechanisms underlying liver pathologies provoked by other insults, such as drug toxicity, where LA could also be a useful agent in therapeutic intervention. However, before wider application of LA in a clinical setting, experimental and clinical research needs to be extended.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS//
dc.rightsopenAccess
dc.sourceArchives of Biological Sciences
dc.subjectα-lipoic acid
dc.subjectDiabetic complications
dc.subjectLiver injury
dc.subjectOxidative stress
dc.subjectNonalcoholic fatty liver disease
dc.subjectDrug toxicity
dc.subject.otherm23
dc.titleBeneficial effects of α-lipoic acid in diabetes- and drug- induced liver injury
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractAрамбашић Јовановић, Јелена; Ускоковић, Aлександра; Динић, Светлана; Грдовић, Невена; Видаковић, Мелита; Познановић, Горан; Михаиловић, Мирјана;
dc.rights.holder© 2018 by the Serbian Biological Society.
dc.identifier.doi10.2298/ABS180503023U
dc.citation.apaUskoković, A., Dinić, S., Grdović, N., Arambašić-Jovanović, J., Vidaković, M., Poznanović, G., & Mihailović, M. (2018). Beneficial effects of α-lipoic acid in diabetes- and drug- induced liver injury. Archives of Biological Sciences, DOI:10.2298/ABS180503023U.
dc.citation.vancouverUskoković A, Dinić S, Grdović N, Arambašić-Jovanović J, Vidaković M, Poznanović G, Mihailović M. Beneficial effects of α-lipoic acid in diabetes- and drug- induced liver injury. Arch Biol Sci. 2018;DOI:10.2298/ABS180503023U.
dc.type.versionacceptedVersion
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/handle/123456789/3072/ArchBiolSci_023U.pdf


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