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dc.creatorDimitrijević, Mirjana
dc.creatorArsenović-Ranin, Nevena
dc.creatorBufan, Biljana
dc.creatorNacka-Aleksić, Mirjana
dc.creatorLazarević Macanović, Mirjana
dc.creatorMilovanović, Petar
dc.creatorĐurić, Marija
dc.creatorSopta, Jelena
dc.creatorLeposavić, Gordana
dc.date.accessioned2018-06-07T08:10:17Z
dc.date.available2018-06-07T08:10:17Z
dc.date.issued2018
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014480017305646?via%3Dihub
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3076
dc.description.abstractCollagen-induced arthritis (CIA) is a frequently used animal model of rheumatoid arthritis, human autoimmune disease that exhibits clear sex bias in incidence and clinical course. Female Dark Agouti rats immunized for CIA showed also greater incidence and higher arthritic score than their male counterparts. The study investigated sex differences in mechanisms controlling the primary immune responses in draining lymph nodes (dLNs), as a factor contributing to this dimorphism. The higher frequencies of CD4 + CD25 + Foxp3- cells, presumably activated effector T (Teff) cells, and IL-17+, IFN-γ + and IL-17 + IFN-γ + T cells were found in female compared with male rat dLNs. However, the frequency of CD4 + CD25 + Foxp3+ T regulatory cells (Treg) did not differ between sexes. Thus, CD4+ Teff cells/Treg ratio, and IL-17+ T cells/Treg and IFN-γ + T cells/Treg ratios were higher in female than in male rats, and among them was found lower frequency of PD-1+ cells. This suggested less efficient control of (auto)immune Th1/Th17 cell responses in female rat dLNs. On the contrary, the frequency of IL-4+ T cells was lower in female than in male rat dLNs. Consistently, the ratio of serum levels of collagen-specific IgG2a (IFN-γ-dependent, with an important pathogenic role in CIA) and IgG1 (IL-4-dependent) was shifted towards IgG2a in female compared with male rats. As a whole, the study suggests that sexual dimorphism in the control of T cell activation/polarization could contribute to sex bias in the susceptibility to CIA. Moreover, the study advises the use of animals of both sexes in the preclinical testing of new drugs for rheumatoid arthritis.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsclosedAccess
dc.sourceExperimental and Molecular Pathology
dc.subjectCIA
dc.subjectDA rat strain
dc.subjectIFN-γ + T cells
dc.subjectIL-17+ T cells
dc.subjectSexual dimorphism
dc.subjectT regulatory cells
dc.subject.otherm21
dc.titleCollagen-induced arthritis in Dark Agouti rats as a model for study of immunological sexual dimorphisms in the human disease.
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractДимитријевић, Мирјана; Миловановић, Петар; Ђурић, Марија; Сопта, Јелена; Лазаревић Мацановић, Мирјана; Aрсеновић-Ранин, Невена; Буфан, Биљана; Нацка-Aлексић, Мирјана; Лепосавић, Гордана;
dc.rights.holder© 2018 Elsevier Inc.
dc.citation.issue1
dc.citation.volume105
dc.identifier.doi10.1016/j.yexmp.2018.05.007
dc.identifier.pmid29792851
dc.identifier.scopus2-s2.0-85047529894
dc.citation.apaDimitrijević, M., Arsenović-Ranin, N., Bufan, B., Nacka-Aleksić, M., Macanović, M. L., Milovanović, P., … Leposavić, G. (2018). Collagen-induced arthritis in Dark Agouti rats as a model for study of immunological sexual dimorphisms in the human disease. Experimental and Molecular Pathology, 105(1), 10–22.
dc.citation.vancouverDimitrijević M, Arsenović-Ranin N, Bufan B, Nacka-Aleksić M, Macanović ML, Milovanović P, Đurić M, Sopta J, Leposavić G. Collagen-induced arthritis in Dark Agouti rats as a model for study of immunological sexual dimorphisms in the human disease. Exp Mol Pathol. 2018;105(1):10–22.
dc.citation.spage10
dc.citation.epage22


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