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dc.creatorVeličković, Nataša
dc.creatorTeofilović, Ana
dc.creatorIlić, Dragana
dc.creatorĐorđević, Ana
dc.creatorVojnović-Milutinović, Danijela
dc.creatorPetrović, Snježana
dc.creatorPreitner, Frederic
dc.creatorTappy, Luc
dc.creatorMatić, Gordana
dc.date2019-05-29
dc.date.accessioned2018-06-07T08:11:43Z
dc.date.available2018-06-07T08:11:43Z
dc.date.issued2018
dc.identifier.urihttp://link.springer.com/10.1007/s00394-018-1730-1
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3077
dc.description.abstractPURPOSE High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator between nutrient-induced stress and inflammation. Thus, we analyzed the effects of high-fructose diet, alone or in combination with chronic stress, on glucose homeostasis, inflammation and expression of energy sensing proteins in the rat liver. METHODS In male Wistar rats exposed to 9-week 20% fructose diet and/or 4-week chronic unpredictable stress we measured plasma and hepatic corticosterone level, indicators of glucose homeostasis and lipid metabolism, hepatic inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4, NLRP3, activation of NFκB, JNK and ERK pathways) and levels of energy-sensing proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α). RESULTS High-fructose diet led to glucose intolerance, activation of NFκB and JNK pathways and increased intrahepatic IL-1β, TNFα and inhibitory phosphorylation of insulin receptor substrate 1 on Ser307. It also decreased phospho-AMPK/AMPK ratio and increased SIRT1 expression. Stress alone increased plasma and hepatic corticosterone but did not influence glucose tolerance, nor hepatic inflammatory or energy-sensing proteins. After the combined treatment, hepatic corticosterone was increased, glucose tolerance remained preserved, while hepatic inflammation was partially prevented despite decreased AMPK activity. CONCLUSION High-fructose diet resulted in glucose intolerance, hepatic inflammation, decreased AMPK activity and reduced insulin sensitivity. Chronic stress alone did not exert such effects, but when applied together with high-fructose diet it could partially prevent fructose-induced inflammation, presumably due to increased hepatic glucocorticoids.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS//
dc.relationSCOPES JRP (Grant no. IZ73ZO_152331)
dc.rightsembargoedAccess
dc.sourceEuropean Journal of Nutrition
dc.subjectAMP-activated protein kinase
dc.subjectDietary fructose
dc.subjectInflammation
dc.subjectRat liver
dc.subjectStress
dc.subject.otherm21
dc.titleModulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress.
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractТаппy, Луц; Војновић-Милутиновић, Данијела; Матић, Гордана; Ђорђевић, Aна; Илић, Драгана; Величковић, Наташа; Теофиловић, Aна; Петровић, Сњежана; Преитнер, Фредериц;
dc.rights.holder© 2018 Springer-Verlag GmbH Germany, part of Springer Nature
dc.description.noteThis is a post-peer-review, pre-copyedit version of an article published in European Journal of Nutrition. The final authenticated version is available online at: [http://dx.doi.org/10.1007/s00394-018-1730-1]
dc.identifier.doi10.1007/s00394-018-1730-1
dc.identifier.pmid29845385
dc.identifier.scopus2-s2.0-85047661903
dc.citation.apaVeličković, N., Teofilović, A., Ilić, D., Djordjevic, A., Vojnović Milutinović, D., Petrović, S., … Matić, G. (2018). Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress. European Journal of Nutrition, DOI:10.1007/s00394-018-1730-1.
dc.citation.vancouverVeličković N, Teofilović A, Ilić D, Djordjevic A, Vojnović Milutinović D, Petrović S, Preitner F, Tappy L, Matić G. Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress. Eur J Nutr. 2018;DOI:10.1007/s00394-018-1730-1.
dc.citation.spage1
dc.citation.epage17
dc.type.versionacceptedVersion


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