Приказ основних података о документу

dc.creatorKrajnović, Tamara
dc.creatorMaksimović-Ivanić, Danijela
dc.creatorMijatović, Sanja
dc.creatorDrača, Dijana
dc.creatorWolf, Katharina
dc.creatorEdeler, David
dc.creatorWessjohann, Ludger A
dc.creatorKaluđerović, Goran N
dc.date.accessioned2018-06-07T08:17:27Z
dc.date.available2018-06-07T08:17:27Z
dc.date.issued2018
dc.identifier.urihttp://www.mdpi.com/2079-4991/8/5/322
dc.identifier.urihttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5977336
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3078
dc.description.abstractIn this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionally, SBA-15 loaded with EO (SBA-15|EO3) does not disturb viability of peritoneal macrophages. SBA-15|EO3 causes inhibition of tumor cell proliferation and triggers apoptosis, connected with caspase activation, upregulation of Bax, as well as Bcl-2 and Bim downregulation along with amplification of poly-(ADP-ribose)-polymerase (PARP) cleavage fragment. Thus, the mesoporous SBA-15 is a promising carrier of the water-insoluble drug emodin.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.rightsopenAccess
dc.sourceNanomaterials (Basel, Switzerland)
dc.subjectSBA-15
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectEmodin
dc.subjectMelanoma
dc.subject.otherm21
dc.titleDrug Delivery System for Emodin Based on Mesoporous Silica SBA-15.
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractWессјоханн, Лудгер A; Крајновић, Тамара; Максимовић-Иванић, Данијела; Мијатовић, Сања; Драча, Дијана; Еделер, Давид; Wолф, Катхарина; Калуђеровић, Горан Н;
dc.rights.holder© 2018 by the authors. Licensee MDPI, Basel, Switzerland
dc.citation.issue5
dc.citation.volume8
dc.identifier.doi10.3390/nano8050322
dc.identifier.pmid29757198
dc.identifier.scopus2-s2.0-85047644167
dc.citation.vancouverKrajnović T, Maksimović-Ivanić D, Mijatović S, Drača D, Wolf K, Edeler D, Wessjohann LA, Kaluđerović GN. Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15. Nanomater (Basel, Switzerland). 2018;8(5):322.
dc.citation.spage322
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/handle/123456789/3078/Nanomater_2018_8_5_322.pdf


Документи

Thumbnail

Овај рад се појављује у следећим колекцијама

Приказ основних података о документу