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dc.creatorKartsev, Victor
dc.creatorLichitsky, Boris
dc.creatorGeronikaki, Athina
dc.creatorPetrou, Anthi
dc.creatorSmiljković, Marija
dc.creatorKostić, Marina
dc.creatorRadanović, Oliver
dc.creatorSoković, Marina
dc.date.accessioned2018-06-07T08:23:45Z
dc.date.available2018-06-07T08:23:45Z
dc.date.issued2018
dc.identifier.urihttp://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00076J#!divAbstract
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3080
dc.description.abstractUsnic acid, a dibenzofuran, was originally isolated from lichens producing secondary metabolites, and is well known as an antibiotic, but is also endowed with several other interesting properties. Thus, the goal of this paper is the design of new usnic acid derivatives and evaluation of their antimicrobial activity. All newly synthesized compounds possess good antibacterial activity with MIC ranging from 1.02-50.93 × 10-2 mmol mL-1 and MBC from 2.05-70.57 × 10-2 mmol mL-1. The most sensitive bacterial species was Staphylococcus aureus, while Pseudomonas aeruginosa and Escherichia coli were the most resistant among the ATCC strains, and MRSA was the most resistant among all tested bacteria (ATCC and clinical isolates). Their antifungal activity was very strong (MIC = 0.35-7.53 × 10-2 mmol mL-1 and MFC = 0.70-15.05 × 10-2 mmol mL-1)-better than those of reference compounds and usnic acid itself. The most sensitive fungal species was Trichoderma viride, while Penicillium versicolor var. cyclopium appeared to be the most resistant. It should be mentioned that in general most of the compounds showed weaker antibacterial activity, but better antifungal properties than usnic acid itself. The results allow us to conclude that the title compounds are good lead compounds for novel more active antibacterial drugs. On the other hand, these compounds are very promising as antifungals.
dc.rightsclosedAccess
dc.sourceMedChemComm
dc.sourceMedChemComm
dc.subjectUsnic acid
dc.subjectAntibacterial
dc.subjectAnticancer
dc.subjectAntitubercular
dc.subject.otherm22
dc.titleDesign, synthesis and antimicrobial activity of usnic acid derivatives
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractРадановић, Оливер; Героникаки, Aтхина; Петроу, Aнтхи; Смиљковић, Марија; Соковић, Марина; Костић, Марина; Картсев, Вицтор; Лицхитскy, Борис;
dc.rights.holder© 2018 The Royal Society of Chemistry
dc.citation.issue5
dc.citation.volume9
dc.identifier.doi10.1039/C8MD00076J
dc.identifier.scopus2-s2.0-85047523362
dc.citation.apaKartsev, V., Lichitsky, B., Geronikaki, A., Petrou, A., Smiljkovic, M., Kostic, M., … Soković, M. (2018). Design, synthesis and antimicrobial activity of usnic acid derivatives. MedChemComm, 9(5), 870–882.
dc.citation.vancouverKartsev V, Lichitsky B, Geronikaki A, Petrou A, Smiljkovic M, Kostic M, Radanovic O, Soković M. Design, synthesis and antimicrobial activity of usnic acid derivatives. Medchemcomm. 2018;9(5):870–82.
dc.citation.spage870
dc.citation.epage882


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