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dc.creatorGarcia, Catarina
dc.creatorSilva, Catarina Oliveira
dc.creatorMonteiro, Carlos M
dc.creatorNicolai, Marisa
dc.creatorViana, Ana
dc.creatorAndrade, Joana M
dc.creatorBarasoain, Isabel
dc.creatorStanković, Tijana
dc.creatorQuintana, José
dc.creatorHernández, Inmaculada
dc.creatorGonzález, Ignacio
dc.creatorEstévez, Francisco
dc.creatorDíaz-Lanza, Ana M
dc.creatorReis, Catarina P
dc.creatorAfonso, Carlos AM
dc.creatorPešić, Milica
dc.creatorRijo, Patrícia
dc.date.accessioned2018-06-22T07:39:44Z
dc.date.available2018-06-22T07:39:44Z
dc.date.issued2018
dc.identifier.urihttps://www.future-science.com/doi/10.4155/fmc-2017-0239
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3086
dc.description.abstractAIM 6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. METHODS/RESULTS Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. CONCLUSION DHR seems to be a promising starting material with anticancer properties to further be explored.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.relationFundação para a Ciência e a Tecnologia
dc.sourceFuture Medicinal Chemistry
dc.subject6,7-dehydroroyleanone
dc.subjectPlectranthus
dc.subjectcytotoxicity
dc.subjectextraction
dc.subjectisolation
dc.subjectmultidrug resistance
dc.subjectnanotechnology
dc.subject.otherm21
dc.titleAnticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction.
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractГарциа, Цатарина; Силва, Цатарина Оливеира; Монтеиро, Царлос М; Ницолаи, Мариса; Виана, Aна; Aндраде, Јоана М; Барасоаин, Исабел; Qуинтана, Јосé; Хернáндез, Инмацулада; Гонзáлез, Игнацио; Естéвез, Францисцо; Пешић, Милица; Дíаз-Ланза, Aна М; Реис, Цатарина П; Aфонсо, Царлос AМ; Ријо, Патрíциа; Станковић, Тијана;
dc.rights.holder© 2018 Newlands Press
dc.citation.issue10
dc.citation.volume10
dc.identifier.doi10.4155/fmc-2017-0239
dc.identifier.pmid29749759
dc.identifier.scopus2-s2.0-85048107643
dc.identifier.wos000433568500005
dc.citation.apaGarcia, C., Silva, C. O., Monteiro, C. M., Nicolai, M., Viana, A., Andrade, J. M., … Rijo, P. (2018). Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction. Future Medicinal Chemistry, 10(10), 1177–1189.
dc.citation.vancouverGarcia C, Silva CO, Monteiro CM, Nicolai M, Viana A, Andrade JM, Barasoain I, Stankovic T, Quintana J, Hernández I, González I, Estévez F, Díaz-Lanza AM, Reis CP, Afonso CA, Pesic M, Rijo P. Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction. Future Med Chem. 2018;10(10):1177–89.
dc.citation.spage1177
dc.citation.epage1189


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