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dc.creatorVelimirović, Milica
dc.creatorJevtić Dožudić, Gordana
dc.creatorSelaković, Vesna
dc.creatorStojković, Tihomir
dc.creatorPuškaš, Nela
dc.creatorZaletel, Ivan
dc.creatorŽivković, Milica
dc.creatorDragutinović, Vesna
dc.creatorNikolić, Tatjana
dc.creatorJelenković, Ankica
dc.creatorĐorović, Đorđe
dc.creatorMirčić, Aleksandar
dc.creatorPetronijević, Nataša D.
dc.date.accessioned2018-11-08T13:49:26Z
dc.date.available2018-11-08T13:49:26Z
dc.date.issued2018
dc.identifier.urihttps://www.hindawi.com/journals/omcl/2018/3273654/
dc.identifier.urihttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5932460
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3167
dc.description.abstractDecreased blood flow in the brain leads to a rapid increase in reactive oxygen species (ROS). NADPH oxidase (NOX) is an enzyme family that has the physiological function to produce ROS. NOX2 and NOX4 overexpression is associated with aggravated ischemic injury, while NOX2/4-deficient mice had reduced stroke size. Dysregulation of matrix metalloproteinases (MMPs) contributes to tissue damage. The active form of vitamin D3 expresses neuroprotective, immunomodulatory, and anti-inflammatory effects in the CNS. The present study examines the effects of the vitamin D3 pretreatment on the oxidative stress parameters and the expression of NOX subunits, MMP9, microglial marker Iba1, and vitamin D receptor (VDR), in the cortex and hippocampus of Mongolian gerbils subjected to ten minutes of global cerebral ischemia, followed by 24 hours of reperfusion. The ischemia/reperfusion procedure has induced oxidative stress, changes in the expression of NOX2 subunits and MMP9 in the brain, and increased MMP9 activity in the serum of experimental animals. Pretreatment with vitamin D3 was especially effective on NOX2 subunits, MMP9, and the level of malondialdehyde and superoxide anion. These results outline the significance of the NOX and MMP9 investigation in brain ischemia and the importance of adequate vitamin D supplementation in ameliorating the injury caused by I/R.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175058/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175061/RS//
dc.relationUniversity of Defence in Belgrade Medical Faculty of the Military Medical Academy (#MFVMA/11/16-18 “Cerebral ischemia - damaging mechanisms and neuroprotection”).
dc.rightsopenAccess
dc.sourceOxidative medicine and cellular longevity
dc.titleEffects of Vitamin D3 on the NADPH Oxidase and Matrix Metalloproteinase 9 in an Animal Model of Global Cerebral Ischemia.
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractПушкаш, Нела; Залетел, Иван; Живковић, Милица; Николић, Татјана; Велимировић, Милица; Јевтић Дожудић, Гордана; Стојковић, Тихомир; Драгутиновић, Весна; Јеленковић, Aнкица; Ђоровић, Ђорђе; Мирчић, Aлександар; Петронијевић, Наташа Д.; Селаковић, Весна;
dc.rights.holder© 2018 Milica Velimirović et al.
dc.citation.volume2018
dc.identifier.doi10.1155/2018/3273654
dc.identifier.pmid29849881
dc.identifier.scopus2-s2.0-85055075298
dc.identifier.scopus
dc.identifier.wos000431211100001
dc.citation.apaVelimirović, M., Jevtić Dožudić, G., Selaković, V., Stojković, T., Puškaš, N., Zaletel, I., … Petronijević, N. D. (2018). Effects of Vitamin D3 on the NADPH Oxidase and Matrix Metalloproteinase 9 in an Animal Model of Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity, 2018, 3273654.
dc.citation.vancouverVelimirović M, Jevtić Dožudić G, Selaković V, Stojković T, Puškaš N, Zaletel I, Živković M, Dragutinović V, Nikolić T, Jelenković A, Djorović D, Mirčić A, Petronijević ND. Effects of Vitamin D3 on the NADPH Oxidase and Matrix Metalloproteinase 9 in an Animal Model of Global Cerebral Ischemia. Oxid Med Cell Longev. 2018;2018:3273654.
dc.citation.spage3273654
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/4559/OxidMedCellLongev_2018_2018_3273654.pdf


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