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dc.creatorJanićijević, Željko
dc.creatorNinkov, Marina
dc.creatorKataranovski, Milena
dc.creatorRadovanović, Filip
dc.date.accessioned2018-12-27T10:40:21Z
dc.date.available2900-01-01
dc.date.issued2018
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.201800322
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3219
dc.description.abstractPoly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173039/RS//
dc.rightsrestrictedAccess
dc.sourceMacromolecular Bioscience
dc.subjectbiocompatibility
dc.subjectdiffusion
dc.subjectdrug delivery systems
dc.subjecthydrogels
dc.subjection exchangers
dc.titlePoly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractРадовановић, Филип; Нинков, Марина; Јанићијевић, Жељко; Катарановски, Милена;
dc.rights.holder© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.identifier.doi10.1002/mabi.201800322
dc.identifier.pmid30548776
dc.identifier.scopus2-s2.0-85058409832
dc.identifier.wos000458369000009
dc.citation.apaJanićijević, Ž., Ninkov, M., Kataranovski, M., & Radovanović, F. (2018). Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. Macromolecular Bioscience, DOI:10.1002/mabi.201800322.
dc.citation.vancouverJanićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. Macromol Biosci. 2018;DOI:10.1002/mabi.201800322.
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dc.citation.rankm21


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