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Impact of general anesthesia on sleep in the experimental model of Parkison's disease neuropathology - possible risks of postoperative recovery

dc.contributor.advisorŠaponjić, Jasna
dc.contributor.advisorAnđus, Pavle
dc.contributor.otherIlić, Tihomir
dc.contributor.otherDacić, Sanja
dc.contributor.otherPetrović, Jelena
dc.creatorLazić, Katarina
dc.date.accessioned2018-05-24T09:51:47Z
dc.date.accessioned2019-03-26T11:00:30Z
dc.date.available2018-05-24T09:51:47Z
dc.date.available2019-03-26T11:00:30Z
dc.date.issued2017
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=5775
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:17640/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1025173682
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/9462
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3295
dc.description.abstractU ovoj doktorskoj disertaciji ispitivan je uticaj ketamin/diazepam i pentobarbital opšte anestezije na EEG mikrostrukturu i obrazac disanja tokom anestezije, kao i na arhitekturu spavanja i strukturu prelaznih stanja, EEG mikrostrukturu i dinamiku epizoda svih faza spavanja nakon anestezije, kako u fiziološkim kontrolama, tako i u eksperimentalnom modelu holinergičke neuropatologije Parkinsonove bolesti (bilateralna lezija PPT jedra).Rezultati ove doktorske disertacije pokazali su da je ketamin/diazepam anestezija operativnog nivoa izazvala ozbiljan poremećaj respiratornog obrasca i EEG mikrostrukture tokom anestezije. Međutim, jednako vreme potrebno za uspostavljanje stabilne anestezije u pacova sa bilateralnom lezijom PPT jedra kao i dugotrajni suprimirajući efekti na povećanu NREM beta i teta amplitudu (elektrofiziološki markeri deficita holinergičkih neurona PPT jedra) nakon anestezije, ukazuju da je ova anestezija potencijalno povoljnija, kako za ulazak u anesteziju, tako i za NREM fazu spavanja nakon operativnih zahvata kod gerijatrijskih pacijenata, kao i pacijenata obolelih od Parkinsonove i Alchajmerove bolesti.Nasuprot ketamin/diazepam anesteziji, pentobarbital anestezija ima povoljnije dejstvo na REM fazu spavanja nakon anestezije, kako kod fizioloških kontrola, tako i u eksperimentalnom modelu holinergičke neuropatologije Parkinsonove bolesti na osnovu: dugotrajnih poremećaja REM spavanja i strukture prelaznih stanja kod fizioloških kontrola koje izaziva ketamin/diazepam anestezija; suprimirajućih efekata obe anestezije operativnog nivoa na produženu REM/REM1 fazu spavanja i poremećaj njihove EEG mikrostrukture kod bilateralne lezije PPT jedra; suprimirajućeg efekta pentobarbital anestezije na povećani broj NREM/REM/NREM prelaza uzrokovanih lezijom PPT jedra; kao i na osnovu EEG mikrostrukture tokom stabilne pentobarbital anestezije, koja se ne razlikuje u poređenju PPT lezije i fiziološke kontrole.sr
dc.description.abstractThe aim of this doctoral dissertation was to follow the impact of ketamine/diazepam and pentobarbital anesthesia on the EEG microstructure and respiratory pattern during anesthesia, and on the post-anesthesia sleep/wake states architecture and transition structure, EEG microstructure across sleep, and all the sleep state episodes dynamics in the physiological condition, as well as during the PPT cholinergic neuropathology (the experimental model of Parkinson’s disease cholinergic neuropathology). Ketamine/diazepam anesthesia induces more alterations in the EEG microstructure and respiratory pattern than does the pentobarbital anesthesia in the PPT lesioned rats. In addition, the equal time required to establish an anesthetized state in the PPT lesioned vs. control rats, and the long-term suppressive effect on augmented NREM beta and theta amplitudes (the hallmarks of PPT cholinergic neuronal loss in rat) suggest ketamine/diazepam anesthesia as potentially more beneficial both for anesthesia induction and for post-anesthesia NREM sleep in the surgical procedures of the elderly, and Parkinson’s, and Alzheimer’s patients. In contrast to the ketamine/diazepam anesthesia the pentobarbital anesthesia is much more beneficial for the post-anesthesia REM sleep in physiological conditions as well as during the PPT cholinergic neuropathology on the basis of: the long-lasting REM sleep and transition structure disorders in physiological controls, induced by the ketamine/diazepam; the abolishing effects of both anesthetic regimens on the post-anesthesia prolonged REM/REM1 sleep and on their EEG microstructure disorders in the PPT lesioned rats; the abolishing effect of pentobarbital on the increased NREM/REM/NREM transitions, caused by the PPT lesion; and the equal EEG microstructure during stable pentobarbital anesthesia in the PPT lesioned rats versus controls.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherBelgrade: University of Belgrade, Faculty of Biologysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173022/RS//
dc.rightsAutorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
dc.rightsopenAccess
dc.sourceUniversity of Belgrade, Faculty of Biologysr
dc.subjectAnestezijasr
dc.subjectAnesthesiaen
dc.subjectPporemećaj spavanjasr
dc.subjectREM faza spavanjasr
dc.subjectSpavanje nakon anestezijesr
dc.subjectPedunkulopontinsko tegmentalno jedrosr
dc.subjectKetamin/diazepamsr
dc.subjectPentobarbitalsr
dc.subjectElektroencefalografijasr
dc.subjectRespiratorni obrazacsr
dc.subjectPacovsr
dc.subjectSleep disorderen
dc.subjectREM sleepen
dc.subjectPost-anesthesia sleepen
dc.subjectPedunculopontine tegmental nucleusen
dc.subjectKetamine/diazepamen
dc.subjectPentobarbitalen
dc.subjectElectroencephalographyenen
dc.subjectRespiratory patternen
dc.subjectRaten
dc.titleUticaj opšte anestezije na spavanje u eksperimentalnom modelu holinergičke neuropatologije Parkinsonove bolesti - mogući rizici postoperativnog oporavkasr
dc.titleImpact of general anesthesia on sleep in the experimental model of Parkison's disease neuropathology - possible risks of postoperative recoveryen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractAнђус, Павле; Шапоњић, Јасна; Илић, Тихомир; Дацић, Сања; Петровић, Јелена; Лазић, Катарина; Утицај опште анестезије на спавање у експерименталном моделу холинергичке неуропатологије Паркинсонове болести - могући ризици постоперативног опоравка; Утицај опште анестезије на спавање у експерименталном моделу холинергичке неуропатологије Паркинсонове болести - могући ризици постоперативног опоравка;
dc.rights.holder© 2017 by the author
dc.citation.vancouverLažić K. Impact of general anesthesia on sleep in the experimental model of Parkison's disease neuropathology - possible risks of postoperative recovery [dissertation]. Belgrade: University of Belgrade, Faculty of Biology; 2017. 106 p.
dc.citation.spage1
dc.citation.epage106
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/4880/Lazic-Katarina-dissertation.pdf


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