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dc.creatorDimitrijević, Mirjana
dc.creatorArsenović-Ranin, Nevena
dc.creatorKosec, Duško
dc.creatorBufan, Biljana
dc.creatorNacka-Aleksić, Mirjana
dc.creatorPilipović, Ivan
dc.creatorLeposavić, Gordana
dc.date.accessioned2020-02-18T11:08:05Z
dc.date.available2020-02-18T11:08:05Z
dc.date.issued2020
dc.identifier.issn2045-2322
dc.identifier.urihttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6985112
dc.identifier.urihttp://ibiss-r.rcub.bg.ac.rs/123456789/3604
dc.description.abstractThe study examined germinal centre (GC) reaction in lymph nodes draining inflamed joints and adjacent tissues (dLNs) in male and female Dark Agouti rat collagen type II (CII)-induced arthritis (CIA) model of rheumatoid arthritis. Female rats exhibiting the greater susceptibility to CIA mounted stronger serum CII-specific IgG response than their male counterparts. This correlated with the higher frequency of GC B cells in female compared with male dLNs. Consistently, the frequency of activated/proliferating Ki-67+ cells among dLN B cells was higher in females than in males. This correlated with the shift in dLN T follicular regulatory (Tfr)/T follicular helper (Tfh) cell ratio towards Tfh cells in females, and greater densities of CD40L and CD40 on their dLN T and B cells, respectively. The higher Tfh cell frequency in females was consistent with the greater dLN expression of mRNA for IL-21/27, the key cytokines involved in Tfh cell generation and their help to B cells. Additionally, in CII-stimulated female rat dLN cell cultures IFN-γ/IL-4 production ratio was shifted towards IFN-γ. Consistently, the serum IgG2a(b)/IgG1 CII-specific antibody ratio was shifted towards an IgG2a(b) response in females. Thus, targeting T-/B-cell interactions should be considered in putative further sex-based translational pharmacology research.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsopenAccess
dc.sourceScientific Reports
dc.subjectAutoimmunity
dc.subjectRheumatic diseases
dc.titleSex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis.
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractБуфан, Биљана; Пилиповић, Иван; Лепосавић, Гордана; Димитријевић, Мирјана; Нацка-Aлексић, Мирјана; Aрсеновић-Ранин, Невена; Косец, Душко;
dc.rights.holder© 2020, The Author(s).
dc.citation.issue1
dc.citation.volume10
dc.identifier.doi10.1038/s41598-020-58127-y
dc.identifier.pmid31988383
dc.identifier.scopus2-s2.0-85078337543
dc.citation.apaDimitrijević, M., Arsenović-Ranin, N., Kosec, D., Bufan, B., Nacka-Aleksić, M., Pilipović, I., et al. (2020). Sex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis. Scientific Reports, 10(1), 1214.
dc.citation.vancouverDimitrijević M, Arsenović-Ranin N, Kosec D, Bufan B, Nacka-Aleksić M, Pilipović I, Leposavić G. Sex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis. Sci Rep. 2020;10(1):1214.
dc.citation.spage1214
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/id/5946/SciRep_2020_10_1_1214.pdf
dc.citation.rankM21


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