Morfometrijske i funkcionalne promene somatotropnih ćelija hipofize ženki pacova posle centralne aplikacije somatostatina
Morphometric and functional changes of female rat pituitary somatotropes after central application of somatostatin
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This study examined the effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 orSRIH-28) on growth and function of pituitary somatotropes (GH cells). Female rats were subjected to intracerebroventricular administration of three 1g doses of SRIH-14 or SRIH-28 every second day. Blood samples were collected for hormone analyses and pituitaries were removed for histological and morphometric evaluation, five days after the last injection. Compared to control animals, SRIH treatment decreased (p<0.05) all morphometric measurements obtained for GH cells. The concentration of serum growth hormone (GH) in SRIH-14- or SRIH-28-treated groups was lower (p<0.05) by 69% and by 61% respectively, in comparison to control rats. These findings suggest that centrally administered somatostatin is specifically involved in the control of growth and secretory activity of GH cells. Thus, pharmacological manipulation of SRIH receptors reached from cerebrospinal fluid may alter the systemic effects of GH.