Od Fentonove reakcije do savremenog koncepta redoks regulacije
From Fenton's reaction to modern concept of redox regulation
Authors:Buzadžić, Biljana J.
Article (Published version)
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Oxidants, antioxidants and free radicals are terms that are associated with daily supplementation of antioxidants in the prevention of a wide range of diseases and pathology. Unfortunately, that kind of thinking, followed by insufficient knowledge of the redox mechanism, popularistically categorizes oxidants and antioxidants as bad and good. This paper is an attempt to examine their role in biological systems with a central place of redox regulation as a life compromise between these two extremes, based on previous knowledge. A try to get a perspective of the protective role of antioxidant and oxidant toxicity, and to perceive a reality in which their activity and/ or concentration in cells determines their role from pathology to the regulation of physiological processes. A special place in that reality is dedicated to gasotransmitters: nitric monoxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S). .