Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova
Age-related changes in the content of insulin: Like growth factor-l in rat brain
Todorović, Vera N.
Drndarević, Neda Č.
Spasić, Slađana Z.
Article (Published version)
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Although there has been extensive research on the effect of IGF-I on muscles and bone tissue, the effect on brain aging has received little attention. We investigated the IGF-I content in brains of differently aged rats. The IGF-I contents in cerebellar and cerebral cortex were found to be higher in immature rats (4-5 days old) compared to young adult (2.5 months old) and middle-aged (7.5-9 months old) rats. However, the decrease of mean IGF-I in middle-aged rats compared to immature animals was statistically significant only in the cerebellar codex. Our results indicate that IGF-I content decreases through the lifespan and maybe selectively in some brain regions.