The effect of olive oil on the plasma transaminase activities and blood hematological values of rats acutely exposed to cadmium
Аутори:Ognjanović, Branka I.
Pavlović, Slađan Z.
Žikić, Radoslav V.
Štajn, Andraš Š.
Maletić, Snežana D.
Petrović, Vojislav M.
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Male Wistar albino 3 months old rats were acutely treated with cadmium (Cd, 0.4 mg/kg b.m., i.p., 24h before the sacrificing), with olive oil (0.4 mL/kg b.m., i.m., 48h before the sacrificing) and Cd+olive oil (in above mentioned amounts). The activities of alanin aminotransaminase (ALT) and aspartat aminotransaminase (AST) in the plasma, as well as hematological values: red blood cells (RBC) count, hematocrite (Ht) value, hemoglobin (Hb) and glucose concentrations were determined in the control and experimental groups of animals. The activities of ALT and AST in the plasma were significantly increased (p<0.005) only in animals treated with cadmium, while in other experimental groups no differences in comparison to controls were found. Our results show a significant alteration of hematological values. The RBC count (p<0.005), as well as Ht value and Hb concentration (p<0.01) were significantly decreased in respect to the control animals. Blood glucose concentration was significantly increased (p<0.005) in rats treated with Cd when compared with control rats. However, pretreatment of rats with olive oil diminished the negative effects of cadmium and shows that olive oil prevents or mitigates anemia caused by cadmium. .