The influence of coenzyme Q10 (CoQ10) on the growth of body mass and somatic indexes in cadmium treated rats
Аутори:Štajn, Andraš Š.
Pavlović, Slađan Z.
Ognjanović, Branka I.
Žikić, Radoslav V.
Petrović, Vojislav M.
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Male 30 days old Wistar albino rats were treated with cadmium (Cd, 17 mg/day/kg body mass in drinking water + 100 μL olive oil, i.m., every fifth day), coenzyme (CoQ10, 16 mg/kg, dissolved in olive oil, i.m., every fifth day), Cd+CoQ10 (17 mg Cd/day kg body mass in drinking water + 16 mg/kg CoQ10, dissolved in olive oil, i.m., every fifth day) and with olive oil (100 μL, i.m., every fifth day) during 30 days. The changes of the body mass growth and somatic indexes were calculated. Our results show that Cd causes significant decrease of body mass growth when administered alone, as well as, in combination with CoQ10. At the same time, treatment with olive oil induces the elevation of the body mass growth. It is established that Cd and Cd+CoQ10 induces significant increase of the mass of kidneys, while CoQ10 increases the mass of all investigated tissues (e.g. liver, kidneys, heart and testes). Treatment with olive oil induces the increase the mass of kidneys and testes. In Cd treated animals somatic indexes were significantly increased for the liver, kidneys and heart. In rats treated with CoQio somatic index was increased only for the liver, while cotreatment with Cd+CoQ10 induces the increase of somatic index only for the kidneys. At the same time, concentration of Cd in the liver, kidneys and testes significantly increased in animals treated with Cd and rats treated concomitantly with Cd+CoQio. .