Antimikrobna aktivnost sekundarnih metabolita izolovanih iz Centaurea spruneri Boiss & Heldr.
Antimicrobial activity of secondary metabolites isolated from Centaurea spruneri Boiss. & Heldr.
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Two coumarins, scopoletin (1) and isoscopoletin (2), two simple phenolic acids, protocatechuic acid (3) and isovanillic acid (4) and one flavonoid, eriodictyol (5) were isolated from the aerial parts of Centaurea spruneri. The structure of the compounds was established by spectroscopic methods. The in vitro antimicrobial activity of the isolated compounds was tested against eight bacteria and eight fungal species, using a microdilution method. All compounds tested showed moderate antibacterial and antifungal activities. Their minimum inhibitory concentrations were in the range 0.655-2.38 µmol ml-1 and their minimal bactericidal concentrations ranged from 0.694 to 4.15 µmol ml-1 against the tested bacterial species. All compounds showed fungistatic activity at 0.259-2.38 µmol ml-1 and fungicidal at 0.69-2.6 µmol ml-1 against all fungi tested.