РАДаР - Репозиторијум Архивираних Дигиталних Радова
Институт за биолошка истраживања "Синиша Станковић"
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ИБИСС РАДаР
  • IBISS
  • Article
  • Преглед рада
  •   ИБИСС РАДаР
  • IBISS
  • Article
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

beta-Glucan administration to diabetic rats alleviates oxidative stress by lowering hyperglycaemia, decreasing non-enzymatic glycation and protein O-GlcNAcylation

2013
Аутори:
Mihailović, Mirjana
Arambašić, Jelena
Uskoković, Aleksandra
Dinić, Svetlana
Grdović, Nevena
Marković, Jelena D
Bauder, Jelena M
Poznanović, Goran
Vidaković, Melita
Тип документа:
Чланак у часопису
Метаподаци
Приказ свих података о документу
Апстракт:
This effect of commercially available beta-glucan-enriched extract (BGEE) in streptozotocin-induced diabetic rats on protein glycation and enzymatic post-translational glycosylation with O-linked N-acetylglucosamine (O-GlcNAc) groups was examined. The BGEE-promoted improvement of diabetic hyperglycaemia was accompanied by significantly lower serum protein glycation. While this revealed an indirect effect of BGEE on protein glycation through its ability to improve hyperglycaemia, the observed BGEE capability to decrease the formation of advanced glycation end-products (AGE) in an in vitro glycation process pointed to its direct glycation-suppressive function in vivo. Compared to untreated diabetic rats, BGEE-treated diabetic rats displayed lower levels of O-GlcNAc-modified liver and kidney antioxidant enzymes, Mn- and CuZn superoxide dismutases and catalase, their improved specific enzymatic activities and increased transcription of genes encoding for them. These results show that BGEE exerts a normalizing effect on diabetes-linked protein modifications, adding to the list of beneficial effects it could provide in diabetes management. (C) 2013 Elsevier Ltd. All rights reserved.
Извор:
Journal of Functional Foods, 2013, 5, 3, 121-1234

ISSN: 1756-4646

[ Google Scholar ]
URI
http://ibiss-r.rcub.bg.ac.rs/123456789/993
Колекције
  • Article
Институција
IBISS

Related items

Showing items related by title, author, creator and subject.

  • Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus) 

    Borković-Mitić, Slavica S.; Prokić, Marko; Krizmanić, Imre I.; Mutić, Jelena; Trifković, Jelena; Gavrić, Jelena; Despotović, Svetlana; Gavrilović, Branka; Radovanović, Tijana; Pavlović, Slađan Z.; Saičić, Zorica (Springer Nature, )
  • Should MTHFR 1298 A>C be tested together with MTHFR 677 C>T polymorphism in women with reproductive challenges? 

    Đurović, Jelena; Stojković, Oliver; Todorović, Jelena; Savić, Kristina; Stamenković, Gorana (GenetikaGenetika, 2017)
  • Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease 

    Šaponjić, Jasna; Petrović, Jelena; Ćirić, Jelena; Lazić, Katarina (Rijeka: InTech, 2016)

DSpace software copyright © 2002-2015  DuraSpace
О ИБИСС РАДаР репозиторијуму | Пошаљите запажања

RCUB
 

 

Комплетан репозиторијумКолекцијеАуториПо датуму издавањаТемеОва институцијаАуториПо датуму издавањаТеме

DSpace software copyright © 2002-2015  DuraSpace
О ИБИСС РАДаР репозиторијуму | Пошаљите запажања

RCUB