Efekat tiroksina na aktivnost antioksidacionih zaštitnih enzima i količinu glutationa u mozgu pacova različite starosti
Effect of thyroxine on antioxidant defense enzyme activities and glutathione content in brain of different maturated rats
Mijalković, Dejan N.
Nikolić, Aleksandra L.
Petrović, Vojislav M.
Article (Published version)
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Effect of thyroxine on antioxidant enzyme activities and GSH content in brain (cortex and rest of the brain) of different maturated rats were studied. Male Mill Hill hybrid hooded rats aged 15, 45 and 75 days were treated with L-thyroxine, T4 (40 μg/100 g body mass), s.c, one dose per day, 14 days (finally aged 30, 60 and 90 days, respectively). Effect of T4 on antioxidant defense (AD) enzyme activities and GSH content in brain differs with respect to age. T4 treatment decrease activities of Mn SOD and CuZn SOD in the rest of the brain of 60 days old rats in comparison to controls and CAT activity in cortex of 30 and 60 day old rats. GSH-Px activity in cortex of 90 days old rats was decreased in T4 treated group in respect to controls, while activity remains unchanged in 30 and 60 day old rats. The activity of GSH-Px in the rest of the brain was unaffected by the treatment in all groups. GSH content in cortex of animals of 30 and 60 days old rats were higher in comparison with corresponding controls, while in 90 days old rats effects were opposite. L- thyroxine treatment significantly decrease GSH content in rest of the brain of 30 days old rats in respect with corresponding controls, while in 60 and 90 days old animals such changes were not detected.
Keywords:antioxidant defense enzymes; glutathione; cerebral cortex; brain; rats; thyroxine
Source:Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 2005, 41, 1, 1-12