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dc.creatorSavić, Tatjana
dc.creatorPatenković, Aleksandra
dc.creatorSoković, Marina
dc.creatorGlamočlija, Jasmina
dc.creatorAnđelković, Marko L.
dc.creatorvan Griensven, Leo JLD
dc.description.abstractThe effect of culinary-medicinal Royal Sun Agaricus (Agaricus brasiliensis) hot water extract on methyl methane sulfonate (MMS) induced mutagenicity/genotoxity in Drosophila melanogaster was studied using a quick and broadly applicable in vivo assay, i.e., the wing somatic mutation and recombination test. We used 2(nd) instar larvae, trans-heterozygous for the third chromosome recessive markers, i.e., multiple wing hairs (mvh) and flare-3 [flr (3)], and fed them for 24 h with the aqueous extract of A. brasiliensis. For antigenotoxicity studies a 24-h pretreatment with the extract was done, followed by a 48-h treatment of the then 3(rd) instar larvae with MMS. The frequency of mutations of the wing blade changes (i.e., of the number of wing spots of different sizes) induced in somatic cells was determined as a parameter of genetic changes of the wing imaginal discs. The results showed that A. brasiliensis extract did not cause any genotoxic or mutagenic effects. No antigenotoxic and/or protective effect against the induction of mutations by MMS was observed. Instead, a possible enhanced mitotic recombination frequency by MMS was seen after pretreatment of the larvae with A. brasiliensis extract. Possible mechanisms of action are discussed.en
dc.description.sponsorshipMinistry of Education and Science of the Republic of Serbia [173012, 173032]sr
dc.sourceInternational Journal of Medicinal Mushroomssr
dc.titleThe Effect of Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al., Extract on Methyl Methanesulfonate Caused Genotoxicity in Drosophila melanogasteren
dcterms.abstractСоковић, Марина; Савић, Татјана; Гламочлија, Јасмина; Патенковић, Aлександра; Aнђелковић, Марко Л.; ван Гриенсвен, Лео ЈЛД;

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