Moguća zaštitna uloga koenzima Q10 na aktivnost antioksidacionih zaštitnih enzima u bubrezima pacova tretiranih kadmijumom
A possible protective role of coenzyme Q10 on antioxidant defense enzyme activities in kidneys of rats treated with cadmium
Ognjanović, Branka I.
Štajn, Andraš Š.
Žikić, Radoslav V.
Radojičić, Ratko M.
Article (Published version)
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The aim of this study is to establish the effects of cadmium (Cd), coenzyme Q10 (CoQ10) and Cd + CoQ10 on the activities of: Superoxide dismutases (total SOD, manganese containing, Mn SOD, copper zinc containing, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), as well as glutathione reductase (GR) in the kidneys of male Wistar albino rats in comparison with control animals. Significantly increased activities of Tot SOD and CuZn SOD in the kidneys of Cd-treated animals were observed. At the same time, the activity of Mn SOD was significantly decreased in the kidneys of animals treated with Cd, as well as with CoQ10. The activity of CAT was significantly lower in rats exposed to CoQ10 and Cd+CoQ10 in respect to the control animals. GSH-Px and GST activities were significantly decreased in all treated groups of animals (Cd, CoQ10 and Cd+CoQ10), while GR activity was not changed. Presented results reveal, that CoQ10 only partially reversed Cd-induced changes of antioxidant defense enzyme activities in kidney by reversing the effect of Cd on Tot SOD and CuZn SOD activities.
Keywords:cadmium; coenzyme Q10; kidneys; antioxidant defense enzymes; rats
Source:Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 2005, 41, 1, 13-20