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dc.creatorVasilijević, Ana
dc.creatorBuzadžić, Biljana J.
dc.creatorKorac, Aleksandra B
dc.creatorPetrović, Vesna
dc.creatorJanković, Aleksandra
dc.creatorMicunović, Ksenija
dc.creatorKorać, Bato
dc.description.abstractAlterations of pancreatic antioxidative defense (AD) and possible nitric oxide (NO) role in AD organization of adult rats receiving L-arginine-HCl (2.25%) or N-omega-nitro-L-arginine methyl ester (L-NAME-HCl, 0.01%) as drinking liquids and maintained at room (22 +/- 1 degrees C) or low (4 +/- 1 degrees C) temperature for 45 days were studied. For that purpose, copper, zinc- and manganese superoxide dismutase (CuZnSOD, MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and glutathione reductase (GR) activities were determined. Cold-induced decrease of CuZnSOD was inhibited with L-NAME, while L-arginine produced the same effect as cold in both supplemented groups. Cold acclimation elevated GSH-Px activity. L-Arginine and L-NAME expressed no effect on GSH-Px in rats kept at room temperature. L-NAME additionally elevated cold-induced GSH-Px activity, L-arginine expressing a similar trend. Cold-induced increase in GST activity was inhibited by L-NAME, while L-arginine inhibited this enzyme in both supplemented groups. Cold acclimation increased GR activity in control and L-NAME-treated group and L-arginine expressed a similar trend. Neither of the treatments affected MnSOD and CAT activities. Cold-induced changes of pancreatic AD were additionally affected by the alterations in L-arginine-NO-producing pathway. Some AD changes in the same direction with L-arginine or L-NAME point to the complexity of nitrogen compounds metabolism and function, accompanied by tissue-specific response. (C) 2007 Elsevier Inc. All rights reserved.en
dc.sourceComparative Biochemistry and Physiology C-Toxicology & Pharmacologysr
dc.titleThe effects of cold acclimation and nitric oxide on antioxidative enzymes in rat pancreasen
dcterms.abstractЈанковић, Aлександра; Василијевић, Aна; Кораћ, Бато М.; Мицуновић, Ксенија; Бузаджић, Биљана Ј.; Корац, Aлександра Б; Петровић, Весна;

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