Different effects of adenosine A1 agonist ribavirin on amphetamine-induced total locomotor and stereotypic activities in rats
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© 2005 New York Academy of Sciences
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Pretreatment with a single dose of ribavirin (10, 20, and 30 mg/kg b.w., i.p.) decreased amphetamine (1.5 mg/kg b.w., i.p.)-induced total locomotor activity (distance traveled) compared to amphetamine alone, but the most significant effect was observed with 30 mg/kg dose. In contrast, total stereotypic activities (such as sniffing, self-grooming, licking, and head weaving) of these animals were unchanged. These findings demonstrate the ability of ribavirin to modulate in a different way central regulation of locomotor and stereotypic activities that in the future could have a practical application in target therapy of some movement disorders.
Keywords:Ribavirin; Amphetamine; Locomotion; Stereotypy; Rats
- Ministry of Science and Environmental Protection of the Republic of Serbia (Contract #1647)
In: Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus. New York, USA: Academy of Sciences; 2005. p. 396-9. (Annals of the New York Academy of Sciences; Vol. 1048).