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dc.creatorTodorović, Natasa A
dc.creatorCorić, T
dc.creatorZhang, P
dc.creatorCanessa, C
dc.date.accessioned2017-11-23T11:15:20Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued2005sr
dc.identifier.issn0077-8923sr
dc.identifier.otherRad_konverzija_3706sr
dc.identifier.urihttps://radar.ibiss.bg.ac.rs/handle/123456789/1711
dc.description.abstractFish ASIC1 (fASIC1) cloned from Opsanus tau, unlike the rat ASICs, requires Ca2+, in the extracellular preconditioning solution (pH 7.4) to be activated. Here we show that fASIC1 is interacting with Ca2+ in the same way as mammalian ASICs: extracellular Ca2+, is increasing the proportion of channels available for activation by stabilizing the closed state of the channel; in the activation process Ca2+ is released; H+ compete for the binding site of Ca2+ making the gating mechanism both Ca2+ and H+ dependent; H+ stabilizes the desensitized state; Ca2+ blocks the fASIC1 channel; and the affinity of the block is also modulated by H+. The "Ca2+ activation requirement" of fASICI reflects its greater affinity for steady-state desensitization by H+ compared to mammalian ASIC1.en
dc.description.sponsorshipnullsr
dc.language.isoEnglishsr
dc.rightsrestrictedAccess
dc.sourceBiophysics from Molecules to Brain: in Memory of Radoslav K. Andjussr
dc.titleEffects of extracellular calcium on fASIC1 currentsen
dc.typeconferenceObject
dc.rights.licenseARR
dcterms.abstractТодоровић, Натаса A; Зханг, П; Цорић, Т; Цанесса, Ц;
dc.citation.issuenullsr
dc.citation.volume1048sr
dc.citation.epage336sr
dc.type.versionpublishedVersionen
dc.citation.rankM21


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