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dc.creatorSamardžić, Tatjana S.
dc.creatorJanković, V
dc.creatorStošić-Grujičić, Stanislava
dc.creatorTrajković, Vladimir S
dc.date.accessioned2017-11-23T11:15:35Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued2001sr
dc.identifier.issn1043-4666sr
dc.identifier.otherRad_konverzija_3815sr
dc.identifier.urihttps://radar.ibiss.bg.ac.rs/handle/123456789/1820
dc.description.abstractThe role of transcription factor STAT1 in production of pro-inflammatory mediators nitric oxide (NO) and IL-6 was examined in murine embryonic fibroblasts. While cells from wild-type animals released large amounts of NO after stimulation with IFN-gamma in combination with LPS, TNF-alpha or IL-1, their STAT1-deficient counterparts failed to synthesise detectable levels of this free radical gas. Inability of STAT1(-/-) fibroblasts to produce NO was accompanied by complete absence of mRNA for iNOS and its transcription factor IRF-1, both readily upregulated in wild-type cells. However, treatment with cytokines (IFN-gamma, TNF-alpha, IL-1, IL-17) significantly increased IL-6 generation in STAT1-deficient fibroblasts. These results indicate that STAT1 activation and subsequent IRF-1 transcription are required for induction of iNOS, but not IL-6 in murine fibroblasts. (C) 2001 Academic Press.en
dc.description.sponsorshipnullsr
dc.language.isoEnglishsr
dc.rightsrestrictedAccess
dc.sourceCytokinesr
dc.titleSTAT1 is required for iNOS activation, but not IL-6 production in murine fibroblastsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈанковић, В; Самарджић, Татјана С.; Стошић-Грујичић, Станислава Д.; Трајковић, Владимир С;
dc.citation.issue3sr
dc.citation.volume13sr
dc.citation.epage182sr
dc.type.versionpublishedVersionen
dc.citation.rankM22


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