Show simple item record

dc.creatorMilošević, Verica
dc.creatorSekulić, Milka I.
dc.creatorBrkić, Branislava
dc.creatorLovren, Mirjana B.
dc.creatorStarčević, Vesna P.
dc.date.accessioned2017-11-23T11:15:36Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued2000sr
dc.identifier.issn0018-2214sr
dc.identifier.otherRad_konverzija_3824sr
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/1829
dc.description.abstractThe effects of intracerebroventricularly administered somatostatin (SRIH-14 or -28) on growth and function of pituitary thyrotropes (TSH-cells) were examined in adult male Wistar rats. The animals were implanted with an intracerebroventricular cannula and after a recovery period, administered three 1 mug doses of SRIH-14 or -28 dissolved in 5 mul saline every second day. Controls were treated in the same way with the same volume of saline only. TSH-producing cells were studied using the peroxidase-antiperoxidase immunohistochemical procedure. Blood samples were collected for hormone (TSH) analyses 5 days after the last injection. Both SRIH-treatments significantly decreased (p < 0.05) all morphometric parameters obtained for TSH-cells in comparison with controls. The volume of TSH-cells decreased by 27%, nuclei by 44% and volume density by 33% in animals treated with SRIH-14. In animals treated with SRIH-28, these parameters were also significantly decreased (p < 0.05) (22%, 31%, and 25% respectively) compared to control rats. Serum concentrations of TSH were significantly decreased (p < 0.05) by 15% in SRIH-14- and by 12% in SRIH-28-treated animals in comparison with the controls. These observations suggest that centrally administered SRIH-14 or -28 is specifically involved in the control of growth and secretory activity of TSH cells.en
dc.description.sponsorshipnullsr
dc.language.isoEnglishsr
dc.rightsrestrictedAccess
dc.sourceHistochemical Journalsr
dc.titleEffect of centrally administered somatostatin on pituitary thyrotropes in male ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилошевић, Верица Љ.; Бркић, Бранислава; Старчевић, Весна П.; Ловрен, Мирјана Б.; Секулић, Милка И.;
dc.citation.issue9sr
dc.citation.volume32sr
dc.citation.epage569sr
dc.type.versionpublishedVersionen
dc.citation.rankM23


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record