Show simple item record

dc.creatorSaičić, Zorica
dc.creatorSimović, MO
dc.creatorKorać, Bato
dc.creatorBlagojević, Duško
dc.creatorBuzadžić, Biljana J.
dc.creatorSpasić, Mihajlo
dc.creatorPetrović, Vojislav M.
dc.date.accessioned2017-11-23T11:17:24Z
dc.date.available2015-11-17T10:26:51Z
dc.date.issued1997sr
dc.identifier.issn0742-8413sr
dc.identifier.otherRad_konverzija_3869sr
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/1874
dc.description.abstractThe activity of antioxidant defense (AD) enzymes-superoxide dismutase (SOD, EC 1.15.1.1.), catalase (CAT, EC 1.11.1.6.), glutathione peroxidase (GSH-Px, EC 1.11.1.9.), glutathione-S-transferase (GST, EC 2.5.1.18), glutathione reductase (GR, EC 1.6.4.2) and glutathione (GSH) content of the anemic Belgrade (b/b) laboratory rats-were measured and analyzed in liver, spleen, lung, heart, brain and testes in comparison with nonanemic controls. The activities of hepatic Mn SOD, CAT, GSH-Px and GST (P < 0.02, P < 0.01 and P < 0.005) were decreased in anemic, comparing with nonanemic animals, whereas the spleen CuZn SOD, Mn SOD, CAT and GSH-Px (P < 0.005, P < 0.02, P < 0.005 and P < 0.01) activities were increased. In the lung of anemic rats, Mn SOD, GSH-Px and GR (P < 0.005, P < 0.01, P < 0.05) activities were higher, whereas GST (P < 0.01) activity was lower in relation to nonanemic ones. In anemic rats, heart Mn SOD (P < 0.05) activity was increased, brain GSH-Px (P < 0.005) activity was lower, whereas GR (P < 0.02) activity was higher compared with nonanemic controls. CuZn SOD (P < 0.05) activity in the testes was elevated and GSH-Px (P < 0.05) reduced in anemic animals. GSH content was decreased in the liver (P < 0.01), lung and brain (P < 0.005) and increased in the spleen (P < 0.02) of anemic rats in relation to the controls. Our data suggest phenotype specific differences in the AD system of the Belgrade (b/b) rat tissues in comparison with nonanemic controls. (C) 1997 Elsevier Science Inc.en
dc.description.sponsorshipnullsr
dc.language.isoEnglishsr
dc.rightsrestrictedAccess
dc.sourceComparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinologysr
dc.titleActivity of antioxidant defense enzymes and glutathione content in some tissues of the Belgrade (b/b) laboratory raten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБлагојевић, Душко П.; Спасић, МБ; Саичић, Зорица; Кораћ, Бато М.; Бузаджић, Биљана Ј.; Петровић, Војислав М.; Симовић, МО;
dc.citation.issue2sr
dc.citation.volume117sr
dc.citation.epage179sr
dc.type.versionpublishedVersionen


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record