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dc.creatorBuzadžić, Biljana J.
dc.creatorVucetic, M.
dc.creatorJankovic, A.
dc.creatorStancic, A.
dc.creatorKorac, A.
dc.creatorKorać, Bato
dc.creatorOtašević, Vesna
dc.date.accessioned2016-05-23T10:59:52Z
dc.date.issued2015
dc.identifier.issn1476-5381
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/1994
dc.description.abstractInfertility is a global problem that is on the rise, especially during the last decade. Currently, infertility affects approximately 10-15\% of the population worldwide. The frequency and origin of different forms of infertility varies. It has been shown that reactive oxygen and nitrogen species (ROS and RNS) are involved in the aetiology of infertility, especially male infertility. Various strategies have been designed to remove or decrease the production of ROS and RNS in spermatozoa, in particular during in vitro fertilization. However, in recent years it has been shown that spermatozoa naturally produce a variety of ROS/RNS, including superoxide anion radical (O-2(-)), hydrogen peroxide and NO. These reactive species, in particular NO, are essential in regulating sperm capacitation and the acrosome reaction, two processes that need to be acquired by sperm in order to achieve fertilization potential. In addition, it has recently been shown that mitochondrial function is positively correlated with human sperm fertilization potential and quality and that NO and NO precursors increase sperm motility by increasing energy production in mitochondria. We will review the new link between sperm NO-driven redox regulation and infertility herein. A special emphasis will be placed on the potential implementation of new redox-active substances that modulate the content of NO in spermatozoa to increase fertility and promote conception. Linked ArticlesThis article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit
dc.description.sponsorshipCOST action {[}BM1005]; Ministry of Education, Science and Technological Development of the Republic of Serbia {[}173054, 173055]
dc.languageEnglish
dc.rightsrestrictedAccess
dc.sourceBritish Journal of Pharmacology
dc.subjectnitric oxide
dc.subjectinfertility
dc.subjectspermatozoa
dc.subjectin vitro fertilization
dc.subjectmitochondria
dc.subjectredox regulation
dc.subjectcapacitation
dc.subjectacrosome reaction
dc.subjectmotility
dc.titleNew insights into male (in)fertility: the importance of NO
dc.typereview
dc.rights.licenseARR
dcterms.abstractЈанковиц, A.; Вуцетиц, М.; Корац, A.; Бузаджић, Биљана Ј.; Оташевић, Весна; Станциц, A.; Кораћ, Бато М.;
dc.citation.issue6, SI
dc.citation.volume172
dc.identifier.doi10.1111/bph.12675
dc.identifier.scopus2-s2.0-84923650701
dc.identifier.wos000350546100005
dc.citation.spage1455
dc.citation.epage1467
dc.type.versionpublishedVersionen


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